Molecular Pathogenesis Unit, Department of Infectious, Parasitic, and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome 00161, Italy.
J Interferon Cytokine Res. 2009 Dec;29(12):765-80. doi: 10.1089/jir.2009.0030.
Members of the interferon regulatory factor (IRF) family are transcription factors implicated in the regulation of a variety of biological processes. Originally identified as intracellular mediators of the induction and biological activities of interferons, their central role in host resistance to pathogens has recently been confirmed by the recognition of their involvement in the regulation of gene expression in responses triggered by Toll-like receptors and other pattern recognition receptors (PRRs). Their function in regulating the development as well as the activity of hematopoietic cells puts them at the interface between innate and adaptive immune responses. IRFs also regulate cell growth and apoptosis in several cell types, thereby affecting susceptibility to and the progression of cancer. In this review the role of some members of the family more deeply involved in the differentiation of hematopoietic cells and in immune regulation is addressed, with a specific focus on T cells and dendritic cells.
干扰素调节因子 (IRF) 家族成员是转录因子，参与多种生物过程的调节。最初被鉴定为干扰素诱导和生物学活性的细胞内介质，其在宿主对病原体的抵抗中的核心作用最近通过识别它们在 Toll 样受体和其他模式识别受体 (PRR) 触发的反应中调节基因表达中的参与得到了证实。它们在调节造血细胞的发育和活性中的作用使它们处于先天和适应性免疫反应之间的界面。IRF 还调节几种细胞类型中的细胞生长和凋亡，从而影响癌症的易感性和进展。在这篇综述中，我们将讨论一些在造血细胞分化和免疫调节中涉及更深的家族成员的作用，特别关注 T 细胞和树突状细胞。
