Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, UK.
Expert Rev Gastroenterol Hepatol. 2009 Dec;3(6):661-79. doi: 10.1586/egh.09.55.
There is increasing evidence that psychological stress and associated mood disorders are linked with, and can adversely affect the course of, inflammatory bowel disease (IBD). Unfortunately, owing to methodological difficulties inherent in undertaking appropriately targeted and blinded trials, there are limited high-quality data regarding the effects on IBD of interventions aimed to ameliorate stress and mood disorders. Nevertheless, patients want psychological intervention as well as conventional medical strategies. Emerging trial evidence supports the suggestion that psychologically orientated therapy may ameliorate IBD-associated mood disorders, but there are no strong data as of yet to indicate that stress management has a beneficial effect on the activity or course of IBD. As yet, which, when and how interventions targeted at psychological stress and mood disturbances should be offered to individual patients with IBD is not clear.
越来越多的证据表明，心理压力和相关的情绪障碍与炎症性肠病（IBD）有关，并可能对其病程产生不利影响。不幸的是，由于开展有针对性和盲法试验所固有的方法学困难，关于旨在改善压力和情绪障碍的干预措施对 IBD 的影响，高质量数据十分有限。然而，患者既需要心理干预，也需要传统的医疗策略。新出现的试验证据支持这样一种观点，即心理导向疗法可能改善与 IBD 相关的情绪障碍，但目前尚无强有力的数据表明，压力管理对 IBD 的活动或病程有有益影响。迄今为止，针对个体 IBD 患者，应提供针对心理压力和情绪紊乱的干预措施，以及提供的时机和方式均不明确。
