Department of Molecular Medicine, Ewha Womans University Medical School, Republic of Korea.
Metab Syndr Relat Disord. 2010 Feb;8(1):21-4. doi: 10.1089/met.2009.0032.
The biophysiology of the amino acid l-arginine has been a field of active research. Agmatine, which is a metabolite of l-arginine, is known to participate in many biophysical reactions, including those in the cardiovascular system. We sought to investigate plasma agmatine levels in human subjects as a potential biomarker for the metabolic syndrome.
Agmatine concentration was measured in plasma from 322 elderly participants in the Ansan Geriatric study. The metabolic syndrome was defined according to an Asian modified version of criteria established in the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. We observed that the metabolic syndrome was associated with low levels of plasma agmatine concentration.
The mean plasma agmatine level in the metabolic syndrome group was lower than that in the non-metabolic syndrome group (79.42 ng/mL vs. 82.44 ng/mL, P = 0.024). Agmatine remained significant within the regression model after adjustment for different covariates (adjusted odds ratio, 0.962; 95% confidence interval, 0.933-0.993).
We concluded that plasma agmatine levels were lower in subjects with the metabolic syndrome than in those without the metabolic syndrome.
氨基酸 l-精氨酸的生物物理学一直是一个活跃的研究领域。胍丁胺是 l-精氨酸的代谢产物，已知参与许多生物物理反应，包括心血管系统中的反应。我们试图研究人类受试者血浆胍丁胺水平作为代谢综合征的潜在生物标志物。
在安山老年研究中，测量了 322 名老年参与者血浆中的胍丁胺浓度。代谢综合征根据美国国家胆固醇教育计划专家小组在第三次报告中制定的标准的亚洲改良版本定义，用于检测、评估和治疗成人高胆固醇血症。我们观察到代谢综合征与血浆胍丁胺浓度降低有关。
代谢综合征组的平均血浆胍丁胺水平低于非代谢综合征组（79.42ng/mL 比 82.44ng/mL，P=0.024）。在调整不同协变量后，胍丁胺在回归模型中仍然具有显著性（调整后的优势比，0.962；95%置信区间，0.933-0.993）。
我们的结论是，代谢综合征患者的血浆胍丁胺水平低于无代谢综合征患者。
