Mehta Purnima, Agrawal Pavi, Luthert Philip, Durrani Omar M
Birmingham and Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, Dudley Road, Birmingham B187QH.
Orbit. 2009;28(6):436-8. doi: 10.3109/01676830903180314.
To describe the clinical findings in a patient who had developed choroidal melanoma and was incidentally found to have meningioma of the optic nerve in the same side.
Clinical and histopathological findings of the case are reviewed and presented.
The patient had a choroidal melanoma of the left eye for which she had initially declined surgery and 2 years later when she underwent an examination, an optic nerve sheath meningioma was incidentally found histologic examination. Both tumours are derived from neural crest cells.
Complex neurocristopathy, a disorder resulting from aberrations in the growth and development of neural crest derived structures has been very rarely described in the eye and orbit. To the best of our knowledge there has been only one previous case report of a combination of neurofibroma in the right upper lid, meningioma in the right middle cranial fossa and uveal malignant melanoma in the left eye. (However in this patient the tumours were at 3 different sites.).
描述一名患有脉络膜黑色素瘤且同侧视神经意外发现有脑膜瘤的患者的临床发现。
回顾并呈现该病例的临床和组织病理学发现。
该患者左眼患有脉络膜黑色素瘤，最初她拒绝手术，2年后接受检查时，组织学检查意外发现视神经鞘脑膜瘤。两种肿瘤均起源于神经嵴细胞。
复杂神经嵴病是一种由神经嵴衍生结构生长发育异常导致的疾病，在眼和眼眶中很少被描述。据我们所知，此前仅有一例右眼睑神经纤维瘤、右中颅窝脑膜瘤和左眼葡萄膜恶性黑色素瘤合并的病例报告。（然而，该患者的肿瘤位于3个不同部位。）
