Torrey Pines Institute for Molecular Studies, Port St. Lucie, Florida 34987, USA.
Mini Rev Med Chem. 2009 Oct;9(11):1272-83. doi: 10.2174/138955709789878105.
High levels of cholesterol are a primary risk factor in the development of cardiovascular diseases. In this review, we have summarized the structural, chemical and computational aspects of hypocholesterolemic drugs, both statins and non-statins, that target enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) to block cholesterol biosynthesis.
高胆固醇水平是心血管疾病发展的主要风险因素。在这篇综述中，我们总结了降低胆固醇药物（包括他汀类药物和非他汀类药物）的结构、化学和计算方面，这些药物靶向酶 3-羟基-3-甲基戊二酰基辅酶 A 还原酶（HMG-CoA）以阻断胆固醇生物合成。
