Novosibirsk Institute of Organic Chemistry, Novosibirsk, Russia.
Mini Rev Med Chem. 2009 Oct;9(11):1317-28. doi: 10.2174/138955709789878123.
Complexation of known drugs with carbohydrate-containing plant metabolites is a promising way to synthesize new drugs that does not only save pharmacological properties of initial agent but also acquire a number of advantageous features such as increased water solubility, bioavailability and decreased toxicity. This review reports on the development and pharmacological evaluation of novel complexes of various well-known drugs with vegetable coplexation agents: glycyrrhizic acid, Stevia glycosides, gypsogenin tetraoside, pectin, xyloglucan, arabinogalactan. The aim of this review is to describe advantages of the new approach, suggested by authors, in the development of low toxic and high-performance drugs.
将已知药物与含碳水化合物的植物代谢物进行络合是一种很有前途的合成新药的方法，它不仅可以保留初始药物的药理特性，还可以获得一些有利的特性，如增加水溶性、生物利用度和降低毒性。本综述报道了各种已知药物与蔬菜络合试剂（甘草酸、甜菊糖苷、羽扇豆四糖苷、果胶、木葡聚糖、阿拉伯半乳聚糖）的新型配合物的开发和药理评价。本综述的目的是描述作者提出的新方法在开发低毒高效药物方面的优势。
