大鼠脑特异性醛缩酶C基因的结构及其区域表达。
The structure of the brain-specific rat aldolase C gene and its regional expression.
作者信息
Mukai T, Yatsuki H, Masuko S, Arai Y, Joh K, Hori K
机构信息
Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
出版信息
Biochem Biophys Res Commun. 1991 Jan 31;174(2):1035-42. doi: 10.1016/0006-291x(91)91523-f.
The rat aldolase C gene was isolated from a rat genomic DNA library. This gene comprises 9 exons and spans 3590 base pairs. A single copy of the gene occurs per haploid rat genome. The initiation of transcription occurs at two different sites. The cellular localization of aldolase C mRNA was determined in the central nervous system along with aldolase A mRNA by in situ hybridization. The result indicates the predominant expression of this gene in Purkinje cells of the cerebellar cortex, where aldolase A mRNA was rather repressed.
大鼠醛缩酶C基因是从大鼠基因组DNA文库中分离出来的。该基因由9个外显子组成，跨度为3590个碱基对。每个单倍体大鼠基因组中该基因只有一个拷贝。转录起始于两个不同的位点。通过原位杂交在中枢神经系统中测定了醛缩酶C mRNA以及醛缩酶A mRNA的细胞定位。结果表明该基因在小脑皮质的浦肯野细胞中主要表达，而醛缩酶A mRNA在那里受到相当程度的抑制。
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