西班牙的血管紧张素 I 转换酶插入/缺失多态性与银屑病或银屑病关节炎之间缺乏关联。

Lack of association between angiotensin I-converting enzyme insertion/deletion polymorphism and psoriasis or psoriatic arthritis in Spain.

机构信息

Dermatología II department, Hospital Universitario Central de Asturias, Oviedo, Spain.

出版信息

Int J Dermatol. 2009 Dec;48(12):1320-3. doi: 10.1111/j.1365-4632.2009.04245.x.

DOI:10.1111/j.1365-4632.2009.04245.x

PMID:19930490

Abstract

Data on the potential influence of the angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) genotype on psoriasis are contradictory. Our aim was to investigate the relationship between the ACE gene I/D polymorphism and psoriasis/psoriatic arthritis. To investigate this, a genetic association study was conducted among 268 unrelated patients with psoriasis and 272 controls. The distribution of DD, ID, and II genotypes did not significantly differ between psoriatic patients and controls (DD: 39.6% vs. 34.2%; ID: 46.3% vs. 53.3%; II: 14.1% vs. 12.5%). In conclusion, the ACE polymorphism is not likely to be associated with either psoriasis or psoriatic arthritis in this study.

摘要

关于血管紧张素转换酶（ACE）插入/缺失（I/D）基因型对银屑病潜在影响的数据存在矛盾。我们的目的是研究 ACE 基因 I/D 多态性与银屑病/银屑病关节炎之间的关系。为此，在 268 例无亲缘关系的银屑病患者和 272 例对照中进行了一项遗传关联研究。DD、ID 和 II 基因型在银屑病患者和对照组之间的分布无显著差异（DD：39.6% vs. 34.2%；ID：46.3% vs. 53.3%；II：14.1% vs. 12.5%）。总之，在本研究中，ACE 多态性与银屑病或银屑病关节炎无关。