Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Crit Care. 2009;13(6):1004. doi: 10.1186/cc8141. Epub 2009 Nov 12.
High mobility group box protein 1 (HMGB1) has been shown to participate in acute inflammatory reactions, including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters, including mortality. Recent studies demonstrated that HMGB1 itself has little or no proinflammatory activity, but is able to potentiate inflammatory responses through binding to mediators, such as endotoxin or cytokines. Important questions are to determine the binding partners for HMGB1 in the setting of severe injury and whether inhibition of interactions of HMGB1 and associated molecules with the cell surface can affect outcome after trauma.
高迁移率族蛋白 B1（HMGB1）已被证明参与急性炎症反应，包括急性肺损伤和败血症。有证据表明，严重创伤后循环中 HMGB1 的水平升高，并与临床重要的预后参数相关，包括死亡率。最近的研究表明，HMGB1 本身几乎没有或没有促炎活性，但能够通过与介质（如内毒素或细胞因子）结合来增强炎症反应。重要的问题是确定严重损伤情况下 HMGB1 的结合伙伴，以及抑制 HMGB1 与相关分子与细胞表面的相互作用是否会影响创伤后的结果。
