胃癌中 P-糖蛋白、肺耐药蛋白和多药耐药相关蛋白的表达及意义。
The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer.
机构信息
Department of Surgery, Heji Hospital Affiliated to Changzhi Medical College, Changzhi 046011, PR China.
出版信息
J Exp Clin Cancer Res. 2009 Nov 24;28(1):144. doi: 10.1186/1756-9966-28-144.
BACKGROUND
To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and the clinico-pathological features.
METHODS
The expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determined by a labbelled Streptavidin-Peroxidase (SP) immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data. None of these patients received chemotherapy prior to surgery.
RESULTS
The positive rates of P-gp, LRP, MRP were 86.4%, 84.7% and 27.1%, respectively. The difference between the positive rate of P-gp and MRP was significant statistically, as well as the difference between the expression of MRP and LRP. No significant difference was observed between P-gp and LRP, but the positively correlation between the expression of P-gp and LRP had been found. No significant correlation between the expression of P-gp, LRP, MRP and the grade of differentiation were observed. The expression of P-gp was correlated with clinical stages positively (r = 0.742), but the difference with the expression of P-gp in different stages was not significant.
CONCLUSION
The expressions of P-gp, LRP and MRP in patients with gastric cancer without prior chemotherapy are high, indicating that innate drug resistance may exist in gastric cancer.
背景
检测多药耐药分子 P-糖蛋白（P-gp）、肺耐药蛋白（LRP）和多药耐药相关蛋白（MRP）的表达，并分析它们与临床病理特征之间的关系。
方法
采用标记链霉亲和素-过氧化物酶（SP）免疫组织化学技术检测 59 例胃癌患者福尔马林固定石蜡包埋组织切片中 P-gp、LRP 和 MRP 的表达，并与临床病理资料进行相关性分析。这些患者均在术前未接受化疗。
结果
P-gp、LRP、MRP 的阳性率分别为 86.4%、84.7%和 27.1%。P-gp 与 MRP 的阳性率差异有统计学意义，MRP 与 LRP 的表达差异也有统计学意义。P-gp 与 LRP 之间的差异无统计学意义，但 P-gp 与 LRP 的表达呈正相关。P-gp、LRP、MRP 的表达与分化程度无显著相关性。P-gp 的表达与临床分期呈正相关（r = 0.742），但不同分期之间 P-gp 表达的差异无统计学意义。
结论
未经化疗的胃癌患者 P-gp、LRP 和 MRP 的表达较高，表明胃癌可能存在固有耐药性。
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