Gong W, Yang Z, Ye W, Du Y, Lu B, Wang M, Li Q, Zhang W, Pan Y, Feng X, Zhou W, Zhang Y, Wen J, Yang Z, Yang Y, Zhu X, Hu Renming
Department of Endocrinology and Metabolism, HuaShan Hospital, Institute of Endocrinology and Diabetology at Fudan University, Shanghai, China.
J Int Med Res. 2009 Sep-Oct;37(5):1486-92. doi: 10.1177/147323000903700525.
The objective of this study was to investigate the relationship between increased prevalence of cardiovascular disease and glucose regulation status in Chinese patients with metabolic syndrome (MetS). All patients underwent an oral glucose tolerance test (2-h post-load plasma glucose) to determine their glucose regulation status and had their brachial-ankle pulse wave velocity (baPWV) measured. Of the 590 patients included in the study, 115 (19.5%) had normal glucose tolerance, 114 (19.3%) had impaired fasting glucose (IFG) alone, 38 (6.4%) had impaired glucose tolerance (IGT) alone, 197 (33.4%) had diabetes mellitus and 126 (21.4%) had combined glucose intolerance (CGI; IFG plus IGT). Patients with diabetes mellitus had a significantly higher baPWV compared with all other groups and patients with CGI had a significantly higher baPWW compared with patients with IFG. Dysglycaemia was common in patients with MetS. An increased prevalence of cardiovascular disease in patients with MetS was related to their glucose regulation status.
本研究的目的是调查中国代谢综合征（MetS）患者心血管疾病患病率增加与血糖调节状态之间的关系。所有患者均接受口服葡萄糖耐量试验（负荷后2小时血浆葡萄糖）以确定其血糖调节状态，并测量其臂踝脉搏波速度（baPWV）。在纳入研究的590例患者中，115例（19.5%）葡萄糖耐量正常，114例（19.3%）仅空腹血糖受损（IFG），38例（6.4%）仅糖耐量受损（IGT），197例（33.4%）患有糖尿病，126例（21.4%）患有复合糖耐量异常（CGI；IFG加IGT）。糖尿病患者的baPWV显著高于所有其他组，CGI患者的baPWV显著高于IFG患者。血糖异常在MetS患者中很常见。MetS患者心血管疾病患病率的增加与其血糖调节状态有关。
