Lu B, Gong W, Yang Z, Yang Z, Yang Y, Wen J, Zhao N, Zhu X, Hu Renming
Department of Endocrinology and Metabolism, HuaShan Hospital, Institute of Endocrinology and Diabetology, Department of Endocrinology and Metabolism, Shanghai Medical College, Fudan University, Shanghai, China.
J Int Med Res. 2009 Sep-Oct;37(5):1493-500. doi: 10.1177/147323000903700526.
The concomitant presence of retinopathy may be helpful in discriminating kidney pathology in type 2 diabetes. This cross-sectional study evaluated the ability to predict the likelihood of patients having diabetic kidney disease (DKD) by comparing the percentage incidence of diabetic retinopathy in different subgroups of Chinese patients with type 2 diabetes (n = 668). The prevalence of chronic kidney disease in the patients was 63.3% (6.6% with DKD, 41.0% with possible DKD and 15.7% with non-diabetic renal disease [NDRD]). The percentage of patients with diabetic retinopathy in the DKD group (63.6%) was significantly higher than in the possible DKD group (24.9%) and the NDRD group (19.0%). DKD was independently associated with diabetic retinopathy based on logistic regression analysis. The likelihood of DKD occurrence as defined by the National Kidney Foundation-Kidney Disease Outcomes Quality Initiative of the USA is applicable to Chinese patients with diabetes. Diabetic retinopathy was more prevalent in patients with DKD compared with patients with possible DKD or NDRD.
视网膜病变的同时存在可能有助于鉴别2型糖尿病患者的肾脏病变情况。这项横断面研究通过比较中国2型糖尿病患者(n = 668)不同亚组中糖尿病视网膜病变的发生率,评估了预测患者患糖尿病肾病(DKD)可能性的能力。患者中慢性肾脏病的患病率为63.3%(6.6%为DKD,41.0%为可能的DKD,15.7%为非糖尿病肾病[NDRD])。DKD组中糖尿病视网膜病变患者的比例(63.6%)显著高于可能的DKD组(24.9%)和NDRD组(19.0%)。基于逻辑回归分析,DKD与糖尿病视网膜病变独立相关。美国国家肾脏基金会-肾脏病预后质量倡议所定义的DKD发生可能性适用于中国糖尿病患者。与可能患有DKD或NDRD的患者相比,DKD患者中糖尿病视网膜病变更为普遍。