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同期放化疗治疗 IIB-IVA 期宫颈癌患者总生存的预后列线图。

Prognostic nomogram for overall survival in stage IIB-IVA cervical cancer patients treated with concurrent chemoradiotherapy.

机构信息

Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan.

出版信息

Am J Obstet Gynecol. 2010 Feb;202(2):174.e1-7. doi: 10.1016/j.ajog.2009.09.028. Epub 2009 Nov 20.


DOI:10.1016/j.ajog.2009.09.028
PMID:19931041
Abstract

OBJECTIVE: On the basis of outcome data from concurrent chemoradiotherapy (CCRT) for locally advanced cervical squamous cell carcinoma, the authors developed a nomogram for predicting survival outcome. STUDY DESIGN: Two hundred fifty-one eligible patients with International Federation of Gynecology and Obstetrics stage IIB-IVA squamous cell carcinoma of the uterine cervix who underwent CCRT were included for the construction of the nomogram. Predictor variables included age, serum squamous cell carcinoma antigen, tumor size, parametrium invasion, hydronephrosis, bladder/rectum invasion, and lymph node metastases. Internal validation of the nomogram was performed. RESULTS: A nomogram for predicting the 5 year overall survival for these patients was constructed on the basis of a Cox regression model from 7 parameters. The concordance index was 0.69. CONCLUSION: This nomogram is a predictive tool, upon external validation, that can be used to counsel patients in predicting outcomes. The discriminatory ability of the nomogram indicates that this population should not be considered homogeneous with respect to risk of death.

摘要

目的:基于同期放化疗治疗局部晚期宫颈鳞状细胞癌的结果数据,作者开发了一种预测生存结局的列线图。

研究设计:本研究纳入了 251 例符合条件的国际妇产科联合会(FIGO)分期为 IIB-IVA 期宫颈鳞状细胞癌患者,这些患者接受了同期放化疗。用于构建列线图的预测变量包括年龄、血清鳞状细胞癌抗原、肿瘤大小、宫旁侵犯、肾积水、膀胱/直肠侵犯和淋巴结转移。对列线图进行了内部验证。

结果:基于 7 个参数的 Cox 回归模型,为这些患者构建了预测 5 年总生存率的列线图。一致性指数为 0.69。

结论:该列线图是一种预测工具,经过外部验证后,可以用于向患者提供预后预测。该列线图的判别能力表明,对于死亡风险而言,该人群不应被视为同质人群。

相似文献

[1]
Prognostic nomogram for overall survival in stage IIB-IVA cervical cancer patients treated with concurrent chemoradiotherapy.

Am J Obstet Gynecol. 2009-11-20

[2]
Predictive factor of distant recurrence in locally advanced squamous cell carcinoma of the cervix treated with concurrent chemoradiotherapy.

Gynecol Oncol. 2008-1

[3]
Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy.

Cancer. 2002-8-1

[4]
[Risk factors and prognosis of node-positive cervical carcinoma].

Ai Zheng. 2005-10

[5]
Can initial serum cyfra 21-1, SCC antigen, and TPA levels in squamous cell cervical cancer predict lymph node metastases or prognosis?

Gynecol Oncol. 2000-4

[6]
Risk stratification of patients with advanced squamous cell carcinoma of cervix treated by radiotherapy alone.

Int J Radiat Oncol Biol Phys. 2005-10-1

[7]
Application of tumor markers CEA, TPA, and SCC-Ag in patients with low-risk FIGO stage IB and IIA squamous cell carcinoma of the uterine cervix.

Gynecol Oncol. 2000-1

[8]
Risk assessment model for overall survival in patients with locally advanced cervical cancer treated with definitive concurrent chemoradiotherapy.

Gynecol Oncol. 2012-10-9

[9]
A nomogram for predicting disease-specific survival after hepatic resection for metastatic colorectal cancer.

Ann Surg. 2008-2

[10]
[Correlation of serum squamous cell carcinoma antigen with clinico-pathological features and prognosis of squamous cell carcinoma of uterine cervix].

Zhonghua Fu Chan Ke Za Zhi. 2007-1

引用本文的文献

[1]
Development and validation of radiomic signature for predicting overall survival in advanced-stage cervical cancer.

Front Nucl Med. 2023-5-17

[2]
Image-guided intensity-modulated radiotherapy in patients with FIGO IIIC1 cervical cancer: efficacy, toxicity and prognosis.

J Cancer. 2023-4-9

[3]
Nomograms Predicting Survival of Cervical Cancer Patients Treated With Concurrent Chemoradiotherapy Based on the 2018 FIGO Staging System.

Front Oncol. 2022-5-11

[4]
Prognostic Analysis and Comparison of the 2014 and 2018 International Federation of Gynecology and Obstetrics Staging System on Overall Survival in Patients with Stage IIB-IVA Cervix Carcinoma.

Int J Womens Health. 2022-3-6

[5]
Development and validation of a prognostic nomogram for 2018 FIGO stages IB1, IB2, and IIA1 cervical cancer: a large multicenter study.

Ann Transl Med. 2022-1

[6]
Prognostic Significance of Clinicopathological Factors Influencing Overall Survival and Event-Free Survival of Patients with Cervical Cancer: A Systematic Review and Meta-Analysis.

Med Sci Monit. 2022-3-9

[7]
Post-recurrence survival in patients with cervical cancer.

Gynecol Oncol. 2022-2

[8]
A therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical model.

Oncoimmunology. 2021

[9]
Mother's knowledge and attitudes towards Visual Acetate Acid Inspection test in Surabaya.

J Public Health Res. 2020-7-2

[10]
Clinical efficacy and prognostic factors of CT-guided I brachytherapy for the palliative treatment of retroperitoneal metastatic lymph nodes.

Cancer Imaging. 2020-4-6

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