男性早发性重度抑郁症与不育有关。

Early-onset Major Depressive Disorder in men is associated with childlessness.

机构信息

Laureate Institute for Brain Research, Tulsa, OK, USA.

出版信息

J Affect Disord. 2010 Jul;124(1-2):187-90. doi: 10.1016/j.jad.2009.10.024.

DOI:10.1016/j.jad.2009.10.024

PMID:19931182

Abstract

METHODS

The self-reported number of children was compared for men and women from the National Epidemiologic Survey of Alcoholism and Related Conditions Survey (NESARC). Subjects with a diagnosis of major depressive disorder or bipolar disorder were compared to those without an axis I disorder. The effect of age, gender, marriage and diagnostic status on number of children was completed using multivariate analyses.

RESULTS

Men with a history of major depressive disorder but not bipolar disorder reported higher rates of childlessness and lower mean number of children. This reduced number of children was related to an early age of onset of MDD. Thirty percent of men with an age of onset of MDD before 22 were childless compared to only 18.9% of men without an axis I disorder (Odds ratio=1.82, 95% CI=1.45-2.27). No effect of mood disorder on number of children was found in women with major depression or bipolar disorder.

DISCUSSION

This study suggests that an early age of onset of major depressive disorder contributes to childlessness in men.

摘要

方法

对来自国家酒精和相关条件流行病学调查（NESARC）的男性和女性进行自我报告的孩子数量比较。将患有重性抑郁障碍或双相情感障碍的患者与无轴 I 障碍的患者进行比较。使用多变量分析完成年龄、性别、婚姻和诊断状况对子女数量的影响。

结果

有重性抑郁障碍但无双相情感障碍病史的男性报告不孕率较高，平均子女数量较少。这种子女数量的减少与 MDD 的发病年龄较早有关。发病年龄在 22 岁之前的 MDD 男性中有 30%没有子女，而没有轴 I 障碍的男性只有 18.9%（比值比=1.82，95%CI=1.45-2.27）。在患有重性抑郁障碍或双相情感障碍的女性中，情绪障碍对子女数量没有影响。