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中链脂肪酸:预防和治疗代谢综合征的功能性脂质。

Medium-chain fatty acids: functional lipids for the prevention and treatment of the metabolic syndrome.

机构信息

Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Honjo-1, Saga 840-8502, Japan.

出版信息

Pharmacol Res. 2010 Mar;61(3):208-12. doi: 10.1016/j.phrs.2009.11.007. Epub 2009 Nov 30.

Abstract

Metabolic syndrome is a cluster of metabolic disorders, such as abdominal obesity, dyslipidemia, hypertension and impaired fasting glucose, that contribute to increased cardiovascular morbidity and mortality. Although the pathogenesis of metabolic syndrome is complicated and the precise mechanisms have not been elucidated, dietary lipids have been recognized as contributory factors in the development and the prevention of cardiovascular risk clustering. This review explores the physiological functions and molecular actions of medium-chain fatty acids (MCFAs) and medium-chain triglycerides (MCTs) in the development of metabolic syndrome. Experimental studies demonstrate that dietary MCFAs/MCTs suppress fat deposition through enhanced thermogenesis and fat oxidation in animal and human subjects. Additionally, several reports suggest that MCFAs/MCTs offer the therapeutic advantage of preserving insulin sensitivity in animal models and patients with type 2 diabetes.

摘要

代谢综合征是一组代谢紊乱,如腹部肥胖、血脂异常、高血压和空腹血糖受损,这些都会增加心血管疾病的发病率和死亡率。尽管代谢综合征的发病机制很复杂,确切机制尚未阐明,但膳食脂质已被认为是心血管风险聚集发展和预防的促成因素。本综述探讨了中链脂肪酸(MCFAs)和中链甘油三酯(MCTs)在代谢综合征发展中的生理功能和分子作用。实验研究表明,膳食 MCFAs/MCTs 通过增强动物和人体的产热和脂肪氧化来抑制脂肪沉积。此外,有几项报告表明,MCFAs/MCTs 在动物模型和 2 型糖尿病患者中具有保持胰岛素敏感性的治疗优势。

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