Xiao Haixiang, Li Wenming, Qin Yi, Lin Zhixiang, Qian Chen, Wu Mingzhou, Xia Yu, Bai Jiaxiang, Geng Dechun
Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230022, China.
Research (Wash D C). 2024 Aug 20;7:0447. doi: 10.34133/research.0447. eCollection 2024.
Bone is a dynamic tissue reshaped by constant bone formation and bone resorption to maintain its function. The skeletal system accounts for approximately 70% of the total volume of the body, and continuous bone remodeling requires quantities of energy and material consumption. Adipose tissue is the main energy storehouse of the body and has a strong adaptive capacity to participate in the regulation of various physiological processes. Considering that obesity and metabolic syndrome have become major public health challenges, while osteoporosis and osteoporotic fractures have become other major health problems in the aging population, it would be interesting to explore these 2 diseases together. Currently, an increasing number of researchers are focusing on the interactions between multiple tissue systems, i.e., multiple organs and tissues that are functionally coordinated together and pathologically pathologically interact with each other in the body. However, there is lack of detailed reviews summarizing the effects of lipid metabolism on bone homeostasis and the interactions between adipose tissue and bone tissue. This review provides a detailed summary of recent advances in understanding how lipid molecules and adipose-derived hormones affect bone homeostasis, how bone tissue, as a metabolic organ, affects lipid metabolism, and how lipid metabolism is regulated by bone-derived cytokines.
骨骼是一种动态组织，通过持续的骨形成和骨吸收进行重塑以维持其功能。骨骼系统约占身体总体积的70%，持续的骨重塑需要大量的能量和物质消耗。脂肪组织是身体的主要能量储存库，具有很强的适应能力，可参与各种生理过程的调节。鉴于肥胖和代谢综合征已成为主要的公共卫生挑战，而骨质疏松症和骨质疏松性骨折已成为老年人群中的其他主要健康问题，将这两种疾病放在一起探讨会很有意思。目前，越来越多的研究人员专注于多个组织系统之间的相互作用，即身体中功能协同且病理上相互影响的多个器官和组织。然而，缺乏详细的综述来总结脂质代谢对骨稳态的影响以及脂肪组织与骨组织之间的相互作用。本综述详细总结了近期在理解脂质分子和脂肪衍生激素如何影响骨稳态、骨组织作为代谢器官如何影响脂质代谢以及骨衍生细胞因子如何调节脂质代谢方面取得的进展。
