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使用 0.35T 开放式磁共振扫描仪的图像进行 HDR 子宫颈治疗计划的施源器重建。

Applicator reconstruction for HDR cervix treatment planning using images from 0.35 T open MR scanner.

机构信息

Clinical Physics Department, Mount Vernon Cancer Centre, Northwood, UK.

出版信息

Radiother Oncol. 2010 Mar;94(3):346-52. doi: 10.1016/j.radonc.2009.10.015. Epub 2009 Nov 20.

Abstract

BACKGROUND AND PURPOSES

Magnetic resonance (MR) imaging is widely recognised as the modality of choice for imaging soft tissue such as the target volume and critical structures relevant to high dose rate (HDR) brachytherapy of the cervix. This work sets out to assess some of the issues faced when introducing this technique clinically compared to the more widely used computed tomography (CT). MR can be used either as the sole imaging modality, or in conjunction with CT.

MATERIALS AND METHODS

Distortion of the images produced by the MR scanner was assessed with a geometrical phantom. Distortion local to the titanium applicators, introduced by the susceptibility of the applicators themselves, was also measured. The technique used to reconstruct applicators is briefly described. An inter-operator study was performed to assess the variability of applicator reconstruction between operators when MR images are used alone to reconstruct the applicators.

RESULTS

A 14-cm cube within which distortion was less than 2mm at all points was identified. The inter-operator study showed some variability in applicator reconstruction with both MR and CT (median MR/CT 1.3mm/0.9 mm, range 0-3.6mm/0-3.3mm). Inter-operator variation in planning target volume (PTV) V 100% and PTV D 90% for MR/CT was 6.1%/3.0% and 7.4%/6.3%, respectively, and D(2cc) OAR doses varied by up to 1.0 Gy between operators for both MR and CT.

CONCLUSIONS

In this study distortion was minimal within a defined volume and inter-observer errors were comparable on MR and CT when used to define applicators and when applied to dose-volume histograms (DVHs). However this does not assure the technique is appropriate with other scanners and applicator sets without further commissioning.

摘要

背景与目的

磁共振(MR)成像被广泛认为是成像软组织的首选方式,例如与宫颈癌高剂量率(HDR)近距离放疗相关的靶区和关键结构。本研究旨在评估与更广泛使用的计算机断层扫描(CT)相比,将该技术引入临床时面临的一些问题。MR 可单独用作成像方式,也可与 CT 结合使用。

材料与方法

使用几何形状体模评估 MR 扫描仪产生的图像失真。还测量了由于应用器本身的磁化率引起的钛应用器局部的失真。简要描述了用于重建应用器的技术。进行了一项操作员间研究,以评估在单独使用 MR 图像重建应用器时,操作员之间在重建应用器时的应用器重建可变性。

结果

确定了一个 14cm 立方体内的所有点的失真都小于 2mm。操作员间研究显示,MR 和 CT 重建的应用器都存在一定的可变性(MR/CT 中位数 1.3mm/0.9mm,范围 0-3.6mm/0-3.3mm)。MR/CT 的计划靶区(PTV)V100%和 PTV D90%的操作员间差异分别为 6.1%/3.0%和 7.4%/6.3%,而 OAR 剂量的 D(2cc)在 MR 和 CT 之间,不同操作员之间的差异高达 1.0Gy。

结论

在本研究中,在定义的体积内,失真最小,在使用 MR 和 CT 定义应用器以及应用于剂量-体积直方图(DVHs)时,观察者间误差具有可比性。但是,如果不进一步进行调试,这并不能保证该技术适用于其他扫描仪和应用器套件。

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