年轻的有胎盘类 X 上的新基因的出现。

The emergence of new genes on the young therian X.

机构信息

Center for Integrative Genomics, University of Lausanne, Genopode Building, CH-1015 Lausanne, Switzerland.

出版信息

Trends Genet. 2010 Jan;26(1):1-4. doi: 10.1016/j.tig.2009.11.001. Epub 2009 Nov 20.

DOI:10.1016/j.tig.2009.11.001

PMID:19931933

Abstract

Recent studies have revealed that our sex chromosomes differentiated relatively recently from ancestral autosomes in the common ancestor of placental and marsupial mammals (therians). Here, we show that the therian X started to accumulate new retroduplicate genes with overall sex-biased expression upon therian sex chromosome differentiation. This process reached its peak within the first approximately 90 million years of sex chromosome evolution and then leveled off. Taken together, our observations suggest that the major sex-related functional remodeling of the X was completed relatively soon after the origination of therian sex chromosomes.

摘要

最近的研究表明，我们的性染色体是在胎盘哺乳动物和有袋类哺乳动物（合弓类动物）的共同祖先的祖先常染色体中相对较近才分化出来的。在这里，我们表明，合弓类动物的 X 染色体在合弓类动物性染色体分化后开始积累具有整体性别偏倚表达的新反转录重复基因。这个过程在性染色体进化的最初大约 9000 万年达到顶峰，然后趋于平稳。总之，我们的观察结果表明，X 染色体的主要性别相关功能重塑在合弓类动物性染色体起源后相对较快地完成。