慢性免疫性血小板减少症中的抗血小板抗体及其在血小板破坏和血小板生成缺陷中的作用。

Antiplatelet antibodies in chronic immune thrombocytopenia and their role in platelet destruction and defective platelet production.

机构信息

Division of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Hematol Oncol Clin North Am. 2009 Dec;23(6):1163-75. doi: 10.1016/j.hoc.2009.08.008.

DOI:10.1016/j.hoc.2009.08.008

PMID:19932426

Abstract

Chronic immune thrombocytopenia (ITP) is an autoimmune disorder manifested by immune-mediated platelet destruction and suppression of platelet production. Chronic ITP characteristically has an insidious onset, usually requires therapy, and is most commonly seen in adults. The diagnosis of chronic ITP is one of exclusion and is based on the American Society of Hematology Guidelines: The patient's history, physical examination, and peripheral blood film must be consistent with the diagnosis and other causes of thrombocytopenia must be ruled out. This article reviews the role of antiplatelet autoantibody in adult chronic ITP.

摘要

慢性免疫性血小板减少症（ITP）是一种自身免疫性疾病，表现为免疫介导的血小板破坏和血小板生成抑制。慢性 ITP 通常具有隐匿性发病，通常需要治疗，最常见于成年人。慢性 ITP 的诊断是排他性诊断，基于美国血液学会指南：患者的病史、体格检查和外周血涂片必须与诊断一致，必须排除其他引起血小板减少症的原因。本文综述了抗血小板自身抗体在成人慢性 ITP 中的作用。