Gaedicke Gerhard, Schulze Harald
Department of Pediatrics and Laboratory for Pediatric Molecular Biology, Otto-Heubner-Centre for Pediatrics and Adolescent Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
Pediatr Blood Cancer. 2006 Oct 15;47(5 Suppl):668-70. doi: 10.1002/pbc.20997.
The cause of idiopathic thrombocytopenia (ITP) is largely unknown, although the underlying pathophysology is an autoimmune process. Anti-idiotypic antibodies and their role on regulatory T-cells might play an important role in the switch from acute to chronic ITP. The exact interaction remains to be elucidated. The effects of the dysregulated immune system and of the autoimmune process on thrombocytopoiesis and megakaryopiesis are ill defined. Therapy of acute and chronic ITP is directed to the risk of bleeding.
特发性血小板减少症（ITP）的病因很大程度上尚不清楚，尽管其潜在的病理生理学是一个自身免疫过程。抗独特型抗体及其在调节性T细胞上的作用可能在急性ITP向慢性ITP的转变中起重要作用。确切的相互作用仍有待阐明。免疫系统失调和自身免疫过程对血小板生成和巨核细胞生成的影响尚不明确。急性和慢性ITP的治疗针对出血风险。
