Smoking Cessation Clinic, Pulmonary and Critical Care Department, Evgenidion Hospital, Athens, Greece.
Ther Adv Respir Dis. 2009 Dec;3(6):279-87. doi: 10.1177/1753465809350653.
This study evaluated the effectiveness of behavioral interventions (brief counseling, nonspecific psychological support in groups - NSGS and cognitive behavioral group therapy - CBGT) in combination with bupropion SR for smoking cessation in the field, through a smoking cessation clinic.
Two-hundred-and-five smokers were enrolled in a 19-week course during 2007/ 2008, and were randomly assigned to: bupropion SR combined with brief counseling (group A), bupropion SR combined with NSGS (group B), bupropion SR combined with CBGT (group C), or CBGT as the only approach (group D).
Continuous abstinence rates at the end of therapy were 53.2% for group A, 62.9% for group B, 50.0% for group C, and 22.2% (p < 0.05) for group D. Sustained abstinence rates in 12 months were 29.6%, 28.1%, 34.3% and 19.4% (p > 0.05), respectively.
Bupropion SR is an effective aid for smoking cessation in clinical practice. NSGT increased the chances for success at the end of therapy when combined with bupropion SR, while CBGT as monotherapy was less effective compared with the approaches including pharmacotherapy. It is suggested that smoking cessation interventions in real-life healthcare settings should be implemented through comprehensive programs using pharmacotherapy where applicable, combined with NSGT, and integrated by specialized healthcare professionals.
本研究通过戒烟门诊评估行为干预（简短咨询、团体中的非特定心理支持 - NSGS 和认知行为团体治疗 - CBGT）联合安非他酮缓释片（bupropion SR）对场域中戒烟的有效性。
2007/2008 年期间，205 名吸烟者参加了为期 19 周的课程，并被随机分配到：安非他酮 SR 联合简短咨询（A 组）、安非他酮 SR 联合 NSGS（B 组）、安非他酮 SR 联合 CBGT（C 组）或仅接受 CBGT（D 组）。
治疗结束时连续戒烟率分别为 A 组 53.2%、B 组 62.9%、C 组 50.0%和 D 组 22.2%（p < 0.05）。12 个月时的持续戒烟率分别为 29.6%、28.1%、34.3%和 19.4%（p > 0.05）。
安非他酮 SR 是临床实践中戒烟的有效辅助手段。当与安非他酮 SR 联合使用时，NSGT 增加了治疗结束时成功的机会，而 CBGT 作为单一疗法的效果不如包括药物治疗在内的方法。建议在现实医疗保健环境中实施戒烟干预措施，应根据需要使用综合方案（包括药物治疗），联合 NSGT，并由专业医疗保健人员进行整合。
