小型综述：核受体、造血作用与干细胞
Minireview: Nuclear receptors, hematopoiesis, and stem cells.
作者信息
Chute John P, Ross Joel R, McDonnell Donald P
机构信息
Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina 27710, USA.
出版信息
Mol Endocrinol. 2010 Jan;24(1):1-10. doi: 10.1210/me.2009-0332. Epub 2009 Nov 24.
Abstract
Nuclear receptors (NRs) regulate a panoply of biological processes, including the function and development of cells within the hematopoietic and immune system, such as erythrocytes, monocytes, and lymphocytes. Significantly less is known regarding the function of NRs in regulating the fate of hematopoietic stem cells (HSCs), the self-renewing, pluripotent cells that give rise to the entirety of the blood and immune systems throughout the lifetime of an individual. Several recent studies suggest, either directly or indirectly, a role for members of the NR family in regulating the differentiation and self-renewal of HSCs, embryonic stem cells, and induced pluripotent stem cells. Herein, we review in detail the function of specific NRs in controlling HSC and other stem cell fate and propose a framework through which these observations can be translated into therapeutic amplification of HSCs for clinical purposes.
摘要
核受体（NRs）调节一系列生物学过程，包括造血和免疫系统中细胞的功能与发育，如红细胞、单核细胞和淋巴细胞。关于核受体在调节造血干细胞（HSCs）命运方面的功能，人们了解得要少得多。造血干细胞是自我更新的多能细胞，在个体的一生中产生整个血液和免疫系统。最近的几项研究直接或间接地表明，核受体家族成员在调节造血干细胞、胚胎干细胞和诱导多能干细胞的分化与自我更新中发挥作用。在此，我们详细综述特定核受体在控制造血干细胞和其他干细胞命运方面的功能，并提出一个框架，通过该框架可将这些观察结果转化为用于临床目的的造血干细胞治疗性扩增。
相似文献
1
Minireview: Nuclear receptors, hematopoiesis, and stem cells.小型综述：核受体、造血作用与干细胞
Mol Endocrinol. 2010 Jan;24(1):1-10. doi: 10.1210/me.2009-0332. Epub 2009 Nov 24.
2
Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells.主角还是反派？维甲酸在造血干细胞调控及其从多能干细胞分化过程中的复杂作用。
Exp Hematol. 2018 Sep;65:1-16. doi: 10.1016/j.exphem.2018.06.287. Epub 2018 Jul 4.
3
Inability of human induced pluripotent stem cell-hematopoietic derivatives to downregulate microRNAs in vivo reveals a block in xenograft hematopoietic regeneration.人诱导多能干细胞-造血衍生物无法在体内下调 microRNAs，揭示了异种造血再生中的障碍。
Stem Cells. 2012 Feb;30(2):131-9. doi: 10.1002/stem.1684.
4
Making a Hematopoietic Stem Cell.制造造血干细胞。
Trends Cell Biol. 2016 Mar;26(3):202-214. doi: 10.1016/j.tcb.2015.10.002. Epub 2015 Oct 31.
5
Use of human embryonic stem cells to understand hematopoiesis and hematopoietic stem cell niche.利用人类胚胎干细胞了解造血过程和造血干细胞龛。
Curr Stem Cell Res Ther. 2010 Sep;5(3):245-50. doi: 10.2174/157488810791824467.
6
Activated HoxB4-induced hematopoietic stem cells from murine pluripotent stem cells via long-term programming.通过长期编程，从鼠多能干细胞中激活的 HoxB4 诱导造血干细胞。
Exp Hematol. 2020 Sep;89:68-79.e7. doi: 10.1016/j.exphem.2020.08.003. Epub 2020 Aug 12.
7
Development of patient-specific hematopoietic stem and progenitor cell grafts from pluripotent stem cells, in vitro.体外诱导多能干细胞分化为患者特异性造血干/祖细胞。
Curr Mol Med. 2013 Jun;13(5):815-20. doi: 10.2174/1566524011313050012.
8
Hematopoietic defects and iPSC disease modeling: lessons learned.造血缺陷与 iPSC 疾病建模：经验教训。
Immunol Lett. 2013 Sep-Oct;155(1-2):18-20. doi: 10.1016/j.imlet.2013.09.018. Epub 2013 Sep 25.
9
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.RUNX1 +24增强子和P1启动子可鉴定出来自人多能干细胞的造血祖细胞的一个独特亚群。
Stem Cells. 2015 Apr;33(4):1130-41. doi: 10.1002/stem.1940.
10
Hematopoietic stem cells: generation and self-renewal.造血干细胞：生成与自我更新。
Cell Death Differ. 2007 Nov;14(11):1851-9. doi: 10.1038/sj.cdd.4402225. Epub 2007 Sep 7.
引用本文的文献
1
The Dynamics of Inducible Genetic Circuits.可诱导遗传回路的动力学
bioRxiv. 2025 May 15:2025.05.11.653320. doi: 10.1101/2025.05.11.653320.
2
NR2F6 regulates stem cell hematopoiesis and myelopoiesis in mice.NR2F6调节小鼠的干细胞造血和骨髓生成。
Front Immunol. 2025 Jan 7;15:1404805. doi: 10.3389/fimmu.2024.1404805. eCollection 2024.
3
Levothyroxine therapy reduces endocan and total cholesterol concentrations in patients with subclinical hypothyroidism.左甲状腺素治疗可降低亚临床甲状腺功能减退患者的内脂素和总胆固醇浓度。
Biochem Med (Zagreb). 2025 Feb 15;35(1). doi: 10.11613/BM.2025.010703. Epub 2024 Dec 15.
4
Nuclear receptor Rev-erbα role in fine-tuning erythropoietin gene expression.核受体 Rev-erbα 在精细调节促红细胞生成素基因表达中的作用。
Blood Adv. 2024 Jul 23;8(14):3705-3717. doi: 10.1182/bloodadvances.2023012228.
5
Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches.当前治疗肝纤维化的研究：在重新利用 FDA 批准的药物和其他新兴方法之间。
J Pharm Pharm Sci. 2023 Nov 7;26:11808. doi: 10.3389/jpps.2023.11808. eCollection 2023.
6
Combined Naïve Bayesian, Chemical Fingerprints and Molecular Docking Classifiers to Model and Predict Androgen Receptor Binding Data for Environmentally- and Health-Sensitive Substances.联合朴素贝叶斯、化学指纹图谱和分子对接分类器，对环境和健康敏感物质的雄激素受体结合数据进行建模和预测。
Int J Mol Sci. 2021 Jun 22;22(13):6695. doi: 10.3390/ijms22136695.
7
Etiopathogenesis, Challenges and Remedies Associated With Female Genital Tuberculosis: Potential Role of Nuclear Receptors.与女性生殖器结核相关的病因发病机制、挑战和补救措施：核受体的潜在作用。
Front Immunol. 2020 Oct 15;11:02161. doi: 10.3389/fimmu.2020.02161. eCollection 2020.
8
Relationship Between Thyroid Hormone Levels and Mean Platelet Count and Volume: Quantitative Assessment.甲状腺激素水平与平均血小板计数及体积的关系：定量评估
Cureus. 2018 Oct 8;10(10):e3421. doi: 10.7759/cureus.3421.
9
Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function.核受体 Nur77 缺失改变树突状细胞功能。
Front Immunol. 2018 Aug 3;9:1797. doi: 10.3389/fimmu.2018.01797. eCollection 2018.
10
Genetic abnormalities associated with acute lymphoblastic leukemia.与急性淋巴细胞白血病相关的基因异常。
Cancer Sci. 2016 Jun;107(6):721-5. doi: 10.1111/cas.12927. Epub 2016 Apr 27.
本文引用的文献
1
Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells.人红细胞生成细胞中糖皮质激素受体与促红细胞生成素受体之间的相互作用。
Exp Hematol. 2009 May;37(5):559-72. doi: 10.1016/j.exphem.2009.02.005.
2
Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension.血管平滑肌细胞选择性过氧化物酶体增殖物激活受体γ缺失导致低血压。
Circulation. 2009 Apr 28;119(16):2161-9. doi: 10.1161/CIRCULATIONAHA.108.815803. Epub 2009 Apr 13.
3
Expression profiling of nuclear receptors in human and mouse embryonic stem cells.人类和小鼠胚胎干细胞中核受体的表达谱分析。
Mol Endocrinol. 2009 May;23(5):724-33. doi: 10.1210/me.2008-0465. Epub 2009 Feb 5.
4
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.利用孤儿核受体Esrrb将成纤维细胞重编程为诱导多能干细胞。
Nat Cell Biol. 2009 Feb;11(2):197-203. doi: 10.1038/ncb1827. Epub 2009 Jan 11.
5
Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.维甲酸受体/维甲酸X受体信号通路的药理学调控可维持培养体系中造血干细胞的自我更新能力。
Mol Endocrinol. 2009 Feb;23(2):188-201. doi: 10.1210/me.2008-0121. Epub 2008 Dec 23.
6
Retinoic acid signaling in development: tissue-specific functions and evolutionary origins.发育过程中的视黄酸信号传导：组织特异性功能及进化起源
Genesis. 2008 Nov;46(11):640-56. doi: 10.1002/dvg.20444.
7
The vitamin D3/Hox-A10 pathway supports MafB function during the monocyte differentiation of human CD34+ hemopoietic progenitors.维生素D3/Hox-A10通路在人CD34+造血祖细胞的单核细胞分化过程中支持MafB功能。
J Immunol. 2008 Oct 15;181(8):5660-72. doi: 10.4049/jimmunol.181.8.5660.
8
Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis.在小鼠胚胎发育过程中指导造血内皮细胞形成和功能的细胞信号传导。
Blood. 2008 Oct 15;112(8):3194-204. doi: 10.1182/blood-2008-02-139055. Epub 2008 Aug 6.
9
Retinoic acid receptors, hematopoiesis and leukemogenesis.维甲酸受体、造血作用与白血病发生
Curr Opin Hematol. 2008 Jul;15(4):346-51. doi: 10.1097/MOH.0b013e3283007edf.
10
Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal.造血干细胞自我更新的内在和外在调控
Nature. 2008 May 15;453(7193):306-13. doi: 10.1038/nature07038.
Zotero 插件