Chute John P, Ross Joel R, McDonnell Donald P
Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina 27710, USA.
Mol Endocrinol. 2010 Jan;24(1):1-10. doi: 10.1210/me.2009-0332. Epub 2009 Nov 24.
Nuclear receptors (NRs) regulate a panoply of biological processes, including the function and development of cells within the hematopoietic and immune system, such as erythrocytes, monocytes, and lymphocytes. Significantly less is known regarding the function of NRs in regulating the fate of hematopoietic stem cells (HSCs), the self-renewing, pluripotent cells that give rise to the entirety of the blood and immune systems throughout the lifetime of an individual. Several recent studies suggest, either directly or indirectly, a role for members of the NR family in regulating the differentiation and self-renewal of HSCs, embryonic stem cells, and induced pluripotent stem cells. Herein, we review in detail the function of specific NRs in controlling HSC and other stem cell fate and propose a framework through which these observations can be translated into therapeutic amplification of HSCs for clinical purposes.
核受体（NRs）调节一系列生物学过程，包括造血和免疫系统中细胞的功能与发育，如红细胞、单核细胞和淋巴细胞。关于核受体在调节造血干细胞（HSCs）命运方面的功能，人们了解得要少得多。造血干细胞是自我更新的多能细胞，在个体的一生中产生整个血液和免疫系统。最近的几项研究直接或间接地表明，核受体家族成员在调节造血干细胞、胚胎干细胞和诱导多能干细胞的分化与自我更新中发挥作用。在此，我们详细综述特定核受体在控制造血干细胞和其他干细胞命运方面的功能，并提出一个框架，通过该框架可将这些观察结果转化为用于临床目的的造血干细胞治疗性扩增。
