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Statins, incident Alzheimer disease, change in cognitive function, and neuropathology.他汀类药物、新发阿尔茨海默病、认知功能变化与神经病理学
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Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial.循环胆固醇水平、载脂蛋白E基因型和痴呆严重程度影响阿托伐他汀治疗阿尔茨海默病的疗效:阿尔茨海默病降胆固醇治疗(ADCLT)试验结果
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Strategies for Primary Prevention of Coronary Heart Disease Based on Risk Stratification by the ACC/AHA Lipid Guidelines, ATP III Guidelines, Coronary Calcium Scoring, and C-Reactive Protein, and a Global Treat-All Strategy: A Comparative--Effectiveness Modeling Study.基于美国心脏病学会/美国心脏协会血脂指南、ATP III指南、冠状动脉钙化评分和C反应蛋白进行风险分层的冠心病一级预防策略,以及全球全治疗策略:一项比较有效性建模研究
PLoS One. 2015 Sep 30;10(9):e0138092. doi: 10.1371/journal.pone.0138092. eCollection 2015.
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Systematic review of atorvastatin for the treatment of Alzheimer's disease.阿托伐他汀治疗阿尔茨海默病的系统评价
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KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer's disease patients.KIF6 719Arg 等位基因与他汀类药物对遗忘型轻度认知障碍和阿尔茨海默病患者胆固醇水平的影响有关。
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本文引用的文献

1
Increased atherogenic lipoproteins are associated with cognitive impairment: effects of statins and subclinical atherosclerosis.致动脉粥样硬化脂蛋白增加与认知障碍相关:他汀类药物和亚临床动脉粥样硬化的影响。
Alzheimer Dis Assoc Disord. 2009 Jan-Mar;23(1):11-7. doi: 10.1097/wad.0b013e3181850188.
2
Use of statins and risk of hospitalization with dementia: a Danish population-based case-control study.他汀类药物的使用与痴呆住院风险:一项基于丹麦人群的病例对照研究。
Alzheimer Dis Assoc Disord. 2009 Jan-Mar;23(1):18-22. doi: 10.1097/WAD.0b013e318180f55b.
3
Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study.一项队列研究中他汀类药物的使用与痴呆症及无痴呆的认知障碍发病率
Neurology. 2008 Jul 29;71(5):344-50. doi: 10.1212/01.wnl.0000319647.15752.7b.
4
Statins, incident Alzheimer disease, change in cognitive function, and neuropathology.他汀类药物、新发阿尔茨海默病、认知功能变化与神经病理学
Neurology. 2008 May 6;70(19 Pt 2):1795-802. doi: 10.1212/01.wnl.0000288181.00826.63. Epub 2008 Jan 16.
5
Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease.他汀类药物治疗与阿尔茨海默病神经病理变化的减少有关。
Neurology. 2007 Aug 28;69(9):878-85. doi: 10.1212/01.wnl.0000277657.95487.1c.
6
Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease.载脂蛋白E基因型对阿尔茨海默病脂质谱影响的研究。
Curr Alzheimer Res. 2006 Apr;3(2):157-60. doi: 10.2174/156720506776383013.
7
Effects of atorvastatin on higher functions.阿托伐他汀对高级功能的影响。
Eur J Clin Pharmacol. 2006 Apr;62(4):259-65. doi: 10.1007/s00228-005-0073-z. Epub 2006 Feb 18.
8
Statin use and the risk of incident dementia: the Cardiovascular Health Study.他汀类药物的使用与新发痴呆症风险:心血管健康研究
Arch Neurol. 2005 Jul;62(7):1047-51. doi: 10.1001/archneur.62.7.1047.
9
APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: the Three-City Study.载脂蛋白E基因型、胆固醇水平、降脂治疗与痴呆:三城市研究
Neurology. 2005 May 10;64(9):1531-8. doi: 10.1212/01.WNL.0000160114.42643.31.
10
Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results.阿托伐他汀治疗轻至中度阿尔茨海默病:初步结果。
Arch Neurol. 2005 May;62(5):753-7. doi: 10.1001/archneur.62.5.753.

On cholesterol levels and statins in cognitive decline and Alzheimer disease: progress and setbacks.

作者信息

Sabbagh Marwan N, Thind Kabir, Sparks David Larry

出版信息

Alzheimer Dis Assoc Disord. 2009 Oct-Dec;23(4):303-5. doi: 10.1097/WAD.0b013e3181a80242.

DOI:10.1097/WAD.0b013e3181a80242
PMID:19935144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2784643/
Abstract
摘要