肾移植中的纤维化发生机制：预防和治疗的潜在靶点。
Fibrogenesis in kidney transplantation: potential targets for prevention and therapy.
机构信息
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53793, USA.
出版信息
Transplantation. 2009 Nov 27;88(10):1149-56. doi: 10.1097/TP.0b013e3181bcccea.
Abstract
Kidney allograft fibrosis results from a reactive process mediated by humoral and cellular events and the activation of transforming growth factor beta1. It is a process that involves both parenchymal and graft infiltrating cells and can lead to organ failure if injury persists or if the response to injury is excessive. In this review, we will address the role of preventive and therapeutic strategies that target kidney allograft fibrogenesis. We conclude that in addition to preventive strategies, therapies based on bone morphogenetic protein 7, hepatocyte growth factor, connective tissue growth factor, and pirfenidone have shown promising results in preclinical studies. Clinical trials are needed to examine the effect of these therapies on long-term outcomes.
摘要
肾移植纤维化是由体液和细胞事件介导的反应过程以及转化生长因子 β1 的激活引起的。这是一个涉及实质细胞和移植物浸润细胞的过程，如果损伤持续存在或对损伤的反应过度，可能导致器官衰竭。在这篇综述中，我们将讨论针对肾移植纤维化的预防和治疗策略的作用。我们的结论是，除了预防策略外，基于骨形态发生蛋白 7、肝细胞生长因子、结缔组织生长因子和吡非尼酮的治疗在临床前研究中显示出了有希望的结果。需要进行临床试验来研究这些治疗方法对长期结果的影响。
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