Department of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
Pediatr Infect Dis J. 2010 Apr;29(4):368-70. doi: 10.1097/INF.0b013e3181c52a04.
Methicillin-resistant Staphylococcus aureus isolates with vancomycin minimal inhibitory concentrations (MICs) >or=1.5 microg/mL have been associated with poorer clinical outcomes and treatment failures in adults. We evaluated vancomycin MICs in 71 invasive pediatric community-acquired MRSA isolates from 2004 to 2008, using the E-test micromethod and the E-test macro-method. The modal MIC by micromethod was 1.5 microg/mL, and median vancomycin MICs did not increase over time.
耐甲氧西林金黄色葡萄球菌（MRSA）分离株的万古霉素最小抑菌浓度（MIC）≥1.5μg/ml 与成人患者的临床转归不良和治疗失败相关。我们使用 E 试验微量法和 E 试验常量法，评估了 2004 年至 2008 年间 71 例侵袭性儿童社区获得性 MRSA 分离株的万古霉素 MIC。微量法的 MIC 中位值为 1.5μg/ml，万古霉素 MIC 中位数并未随时间而增加。
