Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa.
Pediatr Infect Dis J. 2010 Apr;29(4):370-1. doi: 10.1097/INF.0b013e3181c4dada.
There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants.
关于需要抗逆转录病毒治疗的幼儿中传播的抗逆转录病毒耐药性，数据有限。我们采用了世界卫生组织的监测策略，对南非西开普省的抗逆转录病毒初治婴儿（<18 个月）进行检测，在 49 名患者中仅检测到 3 种非核苷类逆转录酶抑制剂（NNRTI），没有检测到 NRTI 或蛋白酶抑制剂监测突变。估计 NRTI 和蛋白酶抑制剂传播的抗逆转录病毒耐药率很低（<5%），这预示着西开普省婴儿的治疗反应良好。
