Lu Jie, Liong Monty, Sherman Sean, Xia Tian, Kovochich Michael, Nel Andre E, Zink Jeffrey I, Tamanoi Fuyuhiko
Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA, California NanoSystems Institute, University of California Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.
Nanobiotechnology. 2007 May 1;3(2):89-95. doi: 10.1007/s12030-008-9003-3.
Biocompatible mesoporous silica nanoparticles, containing the fluorescence dye fluorescein isothiocyanate (FITC), provide a promising system to deliver hydrophobic anticancer drugs to cancer cells. In this study, we investigated the mechanism of uptake of fluorescent mesoporous silica nanoparticles (FMSN) by cancer cells. Incubation with FMSN at different temperatures showed that the uptake was higher at 37 degrees C than at 4 degrees C. Metabolic inhibitors impeded uptake of FMSN into cells. The inhibition of FMSN uptake by nocodazole treatment suggests that microtubule functions are required. We also report utilization of mesoporous silica nanoparticles to deliver a hydrophobic anticancer drug paclitaxel to PANC-1 cancer cells and to induce inhibition of proliferation. Mesoporous silica nanoparticles may provide a valuable vehicle to deliver hydrophobic anticancer drugs to human cancer cells.
含有荧光染料异硫氰酸荧光素（FITC）的生物相容性介孔二氧化硅纳米颗粒，为向癌细胞递送疏水性抗癌药物提供了一个有前景的系统。在本研究中，我们研究了癌细胞摄取荧光介孔二氧化硅纳米颗粒（FMSN）的机制。在不同温度下与FMSN孵育表明，37℃时的摄取量高于4℃时。代谢抑制剂阻碍了FMSN进入细胞。诺考达唑处理对FMSN摄取的抑制表明需要微管功能。我们还报告了利用介孔二氧化硅纳米颗粒向PANC-1癌细胞递送疏水性抗癌药物紫杉醇并诱导增殖抑制。介孔二氧化硅纳米颗粒可能为向人类癌细胞递送疏水性抗癌药物提供一种有价值的载体。
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