van Vlerken Lilian E, Amiji Mansoor M
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA.
Expert Opin Drug Deliv. 2006 Mar;3(2):205-16. doi: 10.1517/17425247.3.2.205.
The use of nanoparticles as drug delivery vehicles for anticancer therapeutics has great potential to revolutionise the future of cancer therapy. As tumour architecture causes nanoparticles to preferentially accumulate at the tumour site, their use as drug delivery vectors results in the localisation of a greater amount of the drug load at the tumour site; thus improving cancer therapy and reducing the harmful nonspecific side effects of chemotherapeutics. In addition, formulation of these nanoparticles with imaging contrast agents provides a very efficient system for cancer diagnostics. Given the exhaustive possibilities available to polymeric nanoparticle chemistry, research has quickly been directed at multi-functional nanoparticles, combining tumour targeting, tumour therapy and tumour imaging in an all-in-one system, providing a useful multi-modal approach in the battle against cancer. This review will discuss the properties of nanoparticles that allow for such multiple functionality, as well as recent scientific advances in the area of multi-functional nanoparticles for cancer therapeutics.
将纳米颗粒用作抗癌治疗的药物递送载体，极有可能彻底改变癌症治疗的未来。由于肿瘤结构会使纳米颗粒优先在肿瘤部位积聚，将其用作药物递送载体可使更多药物负载定位在肿瘤部位；从而改善癌症治疗效果，并减少化疗药物有害的非特异性副作用。此外，将这些纳米颗粒与成像造影剂相结合，可形成一个非常高效的癌症诊断系统。鉴于聚合物纳米颗粒化学具有无穷的可能性，研究很快就转向了多功能纳米颗粒，即将肿瘤靶向、肿瘤治疗和肿瘤成像整合在一个一体化系统中，为对抗癌症提供了一种有用的多模态方法。本综述将讨论纳米颗粒实现这种多功能性的特性，以及多功能纳米颗粒用于癌症治疗领域的最新科学进展。
