他达拉非每日一次用于治疗勃起功能障碍：患者及伴侣的观点。
Tadalafil once daily in the management of erectile dysfunction: patient and partner perspectives.
作者信息
Costa Pierre, Grivel Thierry, Gehchan Naji
机构信息
Service d'Urologie-Andrologie, Hôpital Caremeau, Nîmes, France;
出版信息
Patient Prefer Adherence. 2009 Nov 3;3:105-11. doi: 10.2147/ppa.s3937.
Abstract
Erectile dysfunction (ED) is a prevalent condition that affects men and their partners. Significant improvements in the sexual lives of these couples have been achieved with the introduction of phosphodiesterase 5 (PDE5) inhibitors. A PDE5 inhibitor is now widely recognized as the first-line therapy for the majority of men with ED. Currently, three PDE5 inhibitors - sildenafil, tadalafil and vardenafil - are approved to be taken as needed in anticipation of sexual activity, but only one of these, tadalafil, has been approved to be taken once daily. The primary aims of this review are to summarize the patients' and partners' viewpoints of ED management with PDE5 inhibitors, and to determine whether once-daily tadalafil can contribute to improving some psychological aspects of ED (such as sexual self-confidence, spontaneity and time concerns) compared with on-demand tadalafil or other PDE5 inhibitors taken by patients with ED.
摘要
勃起功能障碍（ED）是一种影响男性及其伴侣的常见病症。随着磷酸二酯酶5（PDE5）抑制剂的引入，这些夫妻的性生活有了显著改善。目前，PDE5抑制剂已被广泛认可为大多数ED男性的一线治疗药物。目前，三种PDE5抑制剂——西地那非、他达拉非和伐地那非——被批准可在预期进行性活动时按需服用，但其中只有他达拉非被批准可每日服用一次。本综述的主要目的是总结患者及其伴侣对使用PDE5抑制剂治疗ED的观点，并确定与按需服用他达拉非或其他ED患者服用的PDE5抑制剂相比，每日一次服用他达拉非是否有助于改善ED的某些心理方面（如性自信心、自然度和时间顾虑）。
相似文献
1
Tadalafil once daily in the management of erectile dysfunction: patient and partner perspectives.他达拉非每日一次用于治疗勃起功能障碍：患者及伴侣的观点。
Patient Prefer Adherence. 2009 Nov 3;3:105-11. doi: 10.2147/ppa.s3937.
2
Treatment satisfaction of men and partners following switch from on-demand phosphodiesterase type 5 inhibitor therapy to tadalafil 5 mg once daily.从按需使用5型磷酸二酯酶抑制剂治疗转换为每日一次服用5毫克他达拉非后男性及其伴侣的治疗满意度
J Sex Med. 2015 Mar;12(3):720-7. doi: 10.1111/jsm.12818. Epub 2015 Jan 23.
3
A randomized open-label trial with a crossover comparison of sexual self-confidence and other treatment outcomes following tadalafil once a day vs. tadalafil or sildenafil on-demand in men with erectile dysfunction.一项随机、开放标签、交叉比较的临床试验，比较每日一次他达拉非与按需使用他达拉非或西地那非治疗勃起功能障碍男性的性自信和其他治疗结局。
J Sex Med. 2012 May;9(5):1418-29. doi: 10.1111/j.1743-6109.2012.02667.x. Epub 2012 Mar 16.
4
A return to normal erectile function with tadalafil once daily after an incomplete response to as-needed PDE5 inhibitor therapy.按需使用 PDE5 抑制剂治疗反应不完全后，每日使用他达拉非恢复正常勃起功能。
J Sex Med. 2014 Mar;11(3):820-30. doi: 10.1111/jsm.12253. Epub 2013 Jul 10.
5
Comparative efficacy of tadalafil once daily in men with erectile dysfunction who demonstrated previous partial responses to as-needed sildenafil, tadalafil, or vardenafil.他达拉非每日一次对既往按需服用西地那非、他达拉非或伐地那非有部分反应的勃起功能障碍男性的疗效比较
Curr Med Res Opin. 2015 Feb;31(2):379-89. doi: 10.1185/03007995.2014.989317. Epub 2014 Dec 2.
6
Treating erectile dysfunction and central neurological diseases with oral phosphodiesterase type 5 inhibitors. Review of the literature.口服磷酸二酯酶 5 抑制剂治疗勃起功能障碍和中枢神经系统疾病。文献复习。
J Sex Med. 2012 Apr;9(4):970-85. doi: 10.1111/j.1743-6109.2011.02615.x. Epub 2012 Feb 3.
7
The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews.5型磷酸二酯酶抑制剂对勃起功能的影响：系统评价综述
Front Pharmacol. 2021 Sep 7;12:735708. doi: 10.3389/fphar.2021.735708. eCollection 2021.
8
Impact on erectile function and sexual quality of life of couples: a double-blind, randomized, placebo-controlled trial of tadalafil taken once daily.对勃起功能及夫妻性生活质量的影响：一项他达拉非每日一次服用的双盲、随机、安慰剂对照试验。
J Sex Med. 2009 May;6(5):1314-23. doi: 10.1111/j.1743-6109.2009.01222.x.
9
Medication utilization behavior in patients receiving phosphodiesterase type 5 inhibitors for erectile dysfunction.接受5型磷酸二酯酶抑制剂治疗勃起功能障碍患者的用药行为。
J Sex Med. 2005 Nov;2(6):848-55. doi: 10.1111/j.1743-6109.2005.00149.x.
10
Patient preference and satisfaction in erectile dysfunction therapy: a comparison of the three phosphodiesterase-5 inhibitors sildenafil, vardenafil and tadalafil.勃起功能障碍治疗中的患者偏好与满意度：西地那非、伐地那非和他达拉非三种磷酸二酯酶-5抑制剂的比较
Patient Prefer Adherence. 2009 Nov 3;3:99-104. doi: 10.2147/ppa.s3349.
引用本文的文献
1
Optimizing access to PrEP based on MSM preferences: results of a discrete choice experiment.基于男男性行为者偏好优化暴露前预防药物的可及性：一项离散选择实验的结果
AIDS Care. 2019 May;31(5):545-553. doi: 10.1080/09540121.2018.1557590. Epub 2018 Dec 15.
2
Evaluation of the long-term safety and effectiveness of tadalafil once daily in Chinese men with erectile dysfunction: interim results of a multicenter, randomized, open-label trial.评价每日一次他达拉非治疗中国勃起功能障碍患者的长期安全性和有效性：多中心、随机、开放标签试验的中期结果。
Asian J Androl. 2018 Nov-Dec;20(6):587-592. doi: 10.4103/aja.aja_47_18.
3
A once-daily dose of tadalafil for erectile dysfunction: compliance and efficacy.他达拉非每日一次给药治疗勃起功能障碍：依从性与疗效
Drug Des Devel Ther. 2010 Sep 7;4:159-71. doi: 10.2147/dddt.s9067.
本文引用的文献
1
Long-term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction.他达拉非5毫克每日一次给药对勃起功能障碍男性的长期安全性和疗效。
J Sex Med. 2008 Sep;5(9):2160-9. doi: 10.1111/j.1743-6109.2008.00935.x. Epub 2008 Jun 28.
2
Investigating women's preference for sildenafil or tadalafil use by their partners with erectile dysfunction: the partners' preference study.调查女性对伴侣使用西地那非或他达拉非治疗勃起功能障碍的偏好：伴侣偏好研究。
J Sex Med. 2008 May;5(5):1198-1207. doi: 10.1111/j.1743-6109.2008.00774.x. Epub 2008 Feb 25.
3
Efficacy of tadalafil once daily in men with diabetes mellitus and erectile dysfunction.他达拉非每日一次给药对糖尿病合并勃起功能障碍男性的疗效。
Diabet Med. 2008 Feb;25(2):138-46. doi: 10.1111/j.1464-5491.2007.02338.x.
4
An evaluation of semen characteristics in men 45 years of age or older after daily dosing with tadalafil 20mg: results of a multicenter, randomized, double-blind, placebo-controlled, 9-month study.45岁及以上男性每日服用20mg他达拉非后的精液特征评估：一项多中心、随机、双盲、安慰剂对照的9个月研究结果
Eur Urol. 2008 May;53(5):1058-65. doi: 10.1016/j.eururo.2007.09.046. Epub 2007 Oct 5.
5
Factors associated with preference for sildenafil citrate and tadalafil for treating erectile dysfunction in men naïve to phosphodiesterase 5 inhibitor therapy: post hoc analysis of data from a multicentre, randomized, open-label, crossover study.首次接受磷酸二酯酶5抑制剂治疗的男性中，与选择西地那非和他达拉非治疗勃起功能障碍相关的因素：一项多中心、随机、开放标签、交叉研究数据的事后分析
BJU Int. 2007 Jul;100(1):122-9. doi: 10.1111/j.1464-410X.2007.06916.x.
6
Tadalafil population pharmacokinetics in patients with erectile dysfunction.他达拉非在勃起功能障碍患者中的群体药代动力学。
Eur J Clin Pharmacol. 2007 Jun;63(6):583-90. doi: 10.1007/s00228-007-0297-1. Epub 2007 Apr 13.
7
Predictors of tadalafil efficacy in men with erectile dysfunction: the SURE study comparing two dosing regimens.他达拉非治疗勃起功能障碍男性疗效的预测因素：比较两种给药方案的SURE研究
J Sex Med. 2006 Nov;3(6):1050-1058. doi: 10.1111/j.1743-6109.2006.00330.x.
8
Prospective, randomized, open-label, fixed-dose, crossover study to establish preference of patients with erectile dysfunction after taking the three PDE-5 inhibitors.一项前瞻性、随机、开放标签、固定剂量、交叉研究，以确定勃起功能障碍患者服用三种磷酸二酯酶-5抑制剂后的偏好。
J Sex Med. 2006 Sep;3(5):901-909. doi: 10.1111/j.1743-6109.2006.00297.x.
9
Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double-blind, placebo-controlled study in the US.他达拉非每日一次给药治疗男性勃起功能障碍：美国一项随机、双盲、安慰剂对照研究
Int J Impot Res. 2007 Jan-Feb;19(1):95-103. doi: 10.1038/sj.ijir.3901496. Epub 2006 Jul 27.
10
Psychosocial outcomes and drug attributes affecting treatment choice in men receiving sildenafil citrate and tadalafil for the treatment of erectile dysfunction: results of a multicenter, randomized, open-label, crossover study.接受枸橼酸西地那非和他达拉非治疗勃起功能障碍的男性患者的心理社会结局及影响治疗选择的药物属性：一项多中心、随机、开放标签、交叉研究的结果
J Sex Med. 2006 Jul;3(4):650-661. doi: 10.1111/j.1743-6109.2006.00261.x.
Zotero 插件