Lustig R A, Krall J M, Curran W J, Hanks G E
Radiation Oncology, Cooper Univ. M. C., Camden, NJ 08103.
Int J Radiat Oncol Biol Phys. 1991 Jan;20(1):101-4. doi: 10.1016/0360-3016(91)90144-s.
The 1978 Patterns of Care Studies (PCS) survey of carcinoma of the larynx reviewed the process (pre-treatment evaluation and treatment) and outcome of 521 patients. When compared to results from the 1973 PCS survey, several important changes have been observed. The use of surgery in conjunction with radiation therapy (RT) increased in Stage III cases from less than 30% to greater than 60% and in Stage IV cases from 48% to greater than 70%. This change in therapy was associated with a decline in locoregional failure in this patient group. Among Stage I and II supra- and subglottic carcinomas, an improvement in 3-year local tumor control (Stage I: 78 to 100% and Stage II: 54 to 74%) and overall freedom from recurrence (Stage I: 78 to 100% and Stage II: 45 to 73%) was seen over this 5-year period with no identifiable change in process for this subgroup. Also noted was an improvement in the freedom from recurrence rate for Stage III and IV patients receiving treatment at facilities with low process scores. The 1978 PCS survey confirmed the presence of superior patient outcome in several subgroups and the relationship of this improvement to patient process.
1978年喉癌治疗模式研究(PCS)对521例患者的治疗过程(治疗前评估和治疗)及治疗结果进行了回顾。与1973年PCS研究的结果相比,观察到了一些重要变化。在III期病例中,手术联合放射治疗(RT)的使用率从不到30%增加到了60%以上,在IV期病例中从48%增加到了70%以上。治疗方式的这种变化与该患者组局部区域失败率的下降相关。在I期和II期声门上和声门下癌中,在这5年期间观察到3年局部肿瘤控制情况有所改善(I期:从78%提高到100%,II期:从54%提高到74%),以及总体无复发生存率有所改善(I期:从78%提高到100%,II期:从45%提高到73%),且该亚组的治疗过程没有明显变化。还注意到,在治疗过程评分较低的机构接受治疗的III期和IV期患者的无复发生存率有所提高。1978年PCS研究证实了几个亚组患者有更好的治疗结果,以及这种改善与患者治疗过程的关系。