Kumar Rajeev, Singh Harkirat, Jacob Mattakaottu, Anand Surendra Pal, Bandopadhyaya Guru Pad
Siemens Ltd India, Healthcare Sector Imaging, New Delhi, India.
Hell J Nucl Med. 2009 Sep-Dec;12(3):248-50.
A method has been developed for the production of (13)N-labeled ammonia in usable quantities with negligible contamination. A system was developed and a process for the production of nitrogen-13 ammonium ions from a target material in the form of a dilute solution of ethanol in natural water, i.e. the bombardment of oxygen-16 with protons within the target material. The system includes a device for producing a proton beam which travels along a pre selected path and strikes the target material in a target chamber. This target chamber is positioned in the path of the proton beam such that subjection of the target material to the beam produces nitrogen-13 atoms and alpha particles. These nitrogen-13 atoms are converted in the aqueous solution to ammonium ions and oxides and are conducted from the target holder to a purification cartridge for collecting a purified product containing the ammonium ions.
已开发出一种方法，可生产出数量可观且污染可忽略不计的（13）N标记氨。开发了一个系统以及一种从天然水中乙醇稀溶液形式的靶材料生产氮-13铵离子的工艺，即在靶材料内用质子轰击氧-16。该系统包括一个用于产生质子束的装置，质子束沿预选路径行进并撞击靶室内的靶材料。该靶室位于质子束路径上，使得靶材料受到束流作用会产生氮-13原子和α粒子。这些氮-13原子在水溶液中转化为铵离子和氧化物，并从靶架传导至净化柱，以收集含有铵离子的纯化产物。
