Department of Neurological Sciences, University of Bologna Medical School, Via U. Foscolo 7, 40123 Bologna, Italy.
J Headache Pain. 2010 Feb;11(1):53-8. doi: 10.1007/s10194-009-0168-5.
Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some common neurobiological pathways. The objective of this study is to assess the role of serotonin metabolism genes in the genetic liability to MOH. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5HTT), serotonin receptor 1A(5-HT1A), serotonin receptor 1B (5-HT1B), serotonin receptor 2A (5-HT2A) and serotonin receptor 6 (5HT6)genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated didnot differ among the three groups. In conclusion, our studydoes not provide evidence that the 5HTT, 5-HT1A, 5HT1B,5HT2A and 5HT6 gene polymorphisms play a role in the genetic predisposition to MOH.
血清素参与了包括痛觉阈值、情绪调节和药物奖赏在内的多种中枢神经系统功能。急性药物滥用被普遍认为是药物过度使用性头痛（MOH）的一个致病因素。显然，MOH 与其他类型的药物成瘾共享一些共同的神经生物学途径。本研究的目的是评估 5-羟色胺代谢基因在 MOH 遗传易感性中的作用。我们使用与 5-羟色胺代谢相关的五个基因（5-羟色胺转运体（5HTT）、5-羟色胺受体 1A（5-HT1A）、5-羟色胺受体 1B（5-HT1B）、5-羟色胺受体 2A（5-HT2A）和 5-羟色胺受体 6（5HT6）基因）的多态性进行了遗传关联研究。我们比较了 138 例 MOH 患者与 117 例无头痛且无药物滥用的对照组，以及 101 例无先兆偏头痛但无药物滥用（MO）的患者。所有研究的多态性的基因型和等位基因分布在三组之间没有差异。总之，我们的研究没有提供证据表明 5HTT、5-HT1A、5HT1B、5HT2A 和 5HT6 基因多态性在 MOH 的遗传易感性中起作用。
