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棉酚及其衍生物与人工膜脂基质的 PVP 配合物的相互作用。

The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix.

机构信息

A.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, 83, st, Kh. Abdullaev, Tashkent, 100125, Uzbekistan.

出版信息

Cell Mol Biol Lett. 2010;15(1):98-117. doi: 10.2478/s11658-009-0037-x. Epub 2009 Nov 20.

DOI:10.2478/s11658-009-0037-x
PMID:19936629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6275622/
Abstract

In this paper, we present the results of a study on the membrane-active properties of gossypol, its derivatives and their polyvinylpyrrolidone complexes as assessed by differential scanning calorimetry and by the fluorescent probe method. The latter revealed the change in polarization of the incident radiation caused by the action of the polyphenol on the artificial membrane lipid matrix.

摘要

本文通过差示扫描量热法和荧光探针法研究了棉酚、其衍生物及其聚乙烯吡咯烷酮复合物的膜活性性质。后者揭示了多酚对人工膜脂基质的作用引起入射辐射偏振的变化。

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本文引用的文献

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The immobilization of gossypol derivative on N-polyvinylpyrrolidone increases its water solubility and modifies membrane-active properties.棉酚衍生物固定于N-聚乙烯吡咯烷酮上可增加其水溶性并改变膜活性性质。
J Med Chem. 2009 Jul 23;52(14):4119-25. doi: 10.1021/jm9002507.
2
Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids.膜脂相的扰动不参与类黄酮对多药耐药相关蛋白1（MRP1）转运活性的调节。
Cell Mol Biol Lett. 2009;14(2):199-221. doi: 10.2478/s11658-008-0044-3. Epub 2008 Nov 19.
3
Investigations on gossypol: past and present developments.棉酚研究：过去与现在的进展
Expert Opin Investig Drugs. 2005 Nov;14(11):1419-34. doi: 10.1517/13543784.14.11.1419.
4
Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis.活性氧非依赖的线粒体途径参与棉酚诱导的细胞凋亡
Arch Biochem Biophys. 2004 Aug 15;428(2):179-87. doi: 10.1016/j.abb.2004.06.007.
5
Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer.
Curr Med Chem. 2003 Dec;10(24):2711-8. doi: 10.2174/0929867033456369.
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The association of glycolytic enzymes with cellular and model membranes.糖酵解酶与细胞膜及模型膜的关联。
Cell Mol Biol Lett. 2003;8(3):667-80.
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Influence of different parameters on drug release from hydrogel systems to a biomembrane model. Evaluation by differential scanning calorimetry technique.不同参数对水凝胶系统向生物膜模型释放药物的影响。采用差示扫描量热法技术进行评估。
Biomaterials. 2000 Apr;21(8):821-33. doi: 10.1016/s0142-9612(99)00252-5.
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Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug.棉酚：未被认可为安全、可逆性男性抗生育药物的原因
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Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol.棉酚各种类似物的抗HIV-1活性及细胞药理学
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