Manabe Noriaki, Hata Jiro, Haruma Ken, Imamura Hiroshi, Kamada Tomoari, Kusunoki Hiroaki
Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan.
Abdom Imaging. 2010 Dec;35(6):637-42. doi: 10.1007/s00261-009-9588-6.
Advances in contrast-enhanced ultrasonography (CEUS) have made it possible to detect leakage of contrast medium. The aim of the present study was to prospectively evaluate the efficacy of CEUS for depiction of active gastrointestinal (GI) bleeding.
Eighty-nine patients (50 men and 39 women with a mean age of 68.6 years) who had evidence of GI bleeding were enrolled. After injection of Sonazoid, CEUS was performed for 2 min. Evidence of active GI bleeding was defined as positive when pooling or leakage of contrast medium was observed in the GI tract. Calculation of the sensitivity, specificity, positive and negative predictive values, and the positive and negative likelihood ratio (LR) for depiction of active GI bleeding by CEUS was done by comparison with GI endoscopy.
The sensitivity, specificity, positive predictive value, and negative predictive value of CEUS for detection of active GI bleeding were 73.7% (95% CI: 48.8, 90.9), 97.1% (95% CI: 90.0, 99.7), 87.5% (95% CI: 61.7, 98.4), and 93.2% (95% CI: 84.7, 97.7), respectively. The positive LR and negative LR were 25.4 and 0.27, respectively.
CEUS is highly effective for the detection of active GI bleeding.
超声造影（CEUS）技术的进步使得检测造影剂渗漏成为可能。本研究的目的是前瞻性评估CEUS对诊断活动性胃肠道（GI）出血的有效性。
纳入89例有GI出血证据的患者（50例男性，39例女性，平均年龄68.6岁）。注射声诺维后，进行2分钟的CEUS检查。当在胃肠道观察到造影剂聚集或渗漏时，活动性GI出血的证据被定义为阳性。通过与GI内镜检查结果对比，计算CEUS诊断活动性GI出血的敏感性、特异性、阳性预测值、阴性预测值以及阳性和阴性似然比（LR）。
CEUS检测活动性GI出血的敏感性、特异性、阳性预测值和阴性预测值分别为73.7%（95%CI：48.8，90.9）、97.1%（95%CI：90.0，99.7）、87.5%（95%CI：61.7，98.4）和93.2%（95%CI：84.7，97.7）。阳性似然比和阴性似然比分别为25.4和0.27。
CEUS对检测活动性GI出血非常有效。
