Department of Hematology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Int J Hematol. 2009 Dec;90(5):605-610. doi: 10.1007/s12185-009-0438-7. Epub 2009 Nov 20.
Extranodal NK/T-cell lymphoma (ENKL), nasal type, is rare and the small intestine is quite extraordinary as a primary lesion site. We report a 47-year-old man with ENKL of the small intestine. He was referred to our hospital because of bloody stool and the diagnosis was made by double-balloon endoscopy (DBE) of the small intestine without surgical procedure. His clinical stage was IVB and he was categorized in group 4 by prognostic index of ENKL. He went into complete remission (CR) after intensive chemotherapy (DeVIC) and subsequently underwent allogeneic bone marrow transplantation (BMT). Although he remained in CR for about 8 months after BMT, he died of disease recurrence 14 months after the diagnosis was made. ENKL of the small intestine follows a highly aggressive course. We describe the usefulness of DBE for diagnosis and management for ENKL of the small intestine. Additional cases, however, should be accumulated to establish optimal treatment strategy.
结外 NK/T 细胞淋巴瘤（ENKL），鼻型，较为罕见，小肠作为原发性病变部位则更为少见。我们报告了一例小肠 ENKL 患者，男，47 岁，因血便就诊，小肠双气囊内镜（DBE）检查明确诊断，未行手术治疗。该患者临床分期为 IVB 期，ENKL 预后指数分组为 4 组。经密集化疗（DeVIC）后达到完全缓解（CR），随后行异基因骨髓移植（BMT）。BMT 后约 8 个月仍处于 CR 期，但在确诊后 14 个月死于疾病复发。小肠 ENKL 具有高度侵袭性。我们描述了 DBE 对小肠 ENKL 的诊断和治疗价值。然而，还需要更多的病例来建立最佳的治疗策略。
