Padayachy Llewellyn C, Figaji Anthony A, Bullock M R
Division of Neurosurgery, School of Child and Adolescent Health, Red Cross Children's Hospital, University of Cape Town, Cape Town, South Africa.
Childs Nerv Syst. 2010 Apr;26(4):441-52. doi: 10.1007/s00381-009-1034-0.
Intracranial pressure (ICP) has become a cornerstone of care in adult and pediatric patients with traumatic brain injury (TBI).
Despite the fact that continuous monitoring of ICP in TBI was described almost 60 years ago, there are no randomized trials confirming the benefit of ICP monitoring and treatment in TBI. There is, however, a large body of clinical evidence showing that ICP monitoring influences treatment and leads to better outcomes if part of protocol-driven therapy. However, treatment of ICP has adverse effects, and there are several questions about ICP management that have yet to be definitively answered, particularly in pediatric TBI. This review examines the history and evolution of ICP monitoring, pathophysiological concepts that influence ICP interpretation, ongoing controversies, and the place of ICP monitoring in modern neurocritical care.
颅内压(ICP)已成为成人和儿童创伤性脑损伤(TBI)护理的基石。
尽管在近60年前就已描述了对TBI患者进行颅内压的连续监测,但尚无随机试验证实颅内压监测及治疗对TBI的益处。然而,有大量临床证据表明,颅内压监测会影响治疗,并且如果作为方案驱动治疗的一部分,会带来更好的结果。然而,颅内压治疗存在不良反应,关于颅内压管理仍有几个问题尚未得到明确解答,尤其是在儿童TBI中。本综述探讨了颅内压监测的历史与演变、影响颅内压解读的病理生理概念、持续存在的争议以及颅内压监测在现代神经重症监护中的地位。