Van't Hoff W, Bicknell E J, Horrocks P M, Fleetwood J A, Inthuprapa M, Hall R
Clin Chim Acta. 1977 Oct 15;80(2):373-9. doi: 10.1016/0009-8981(77)90046-8.
Eighteen consecutive hirsute women attending an endocrine clinic have been studied by measurement of the urinary pregnanetriol excretion before and following the concurrent administration of corticotrophin and metyrapone. An abnormal increment in pregnanetriol excretion was observed in 11 of these 18 patients. It is suggested that this is evidence that an adrenal abnormality, probably operative at the 21-hydroxylase level, might be a factor responsible for the hirsutism in these 11 patients. Five adrenalectomized women who were also studied showed no significant increase in urinary pregnanetriol excretion in response to concurrent corticotrophin and metyrapone administration.
对连续18名在内分泌门诊就诊的多毛女性患者，在同时给予促肾上腺皮质激素和甲吡酮前后分别测定其尿孕三醇排泄量进行研究。这18例患者中有11例观察到孕三醇排泄量异常增加。提示这证明肾上腺异常（可能在21 - 羟化酶水平起作用）可能是这11例患者多毛症的一个原因。对另外5例接受肾上腺切除术的女性患者进行研究，结果显示在同时给予促肾上腺皮质激素和甲吡酮后，其尿孕三醇排泄量无显著增加。
