Hepatic Surgery and Liver Transplant Unit, La Fe University Hospital, Valencia, Spain.
Liver Transpl. 2009 Dec;15(12):1709-17. doi: 10.1002/lt.21945.
University of Wisconsin solution (UWS) is the gold standard for graft preservation. Celsior solution (CS) is a new solution not as yet widely used in liver grafts. The aim of this study was to compare the liver function of transplanted grafts stored in these 2 preservation solutions. The primary endpoints were the rates of primary nonfunction (PNF) and primary dysfunction (PDF). We performed a prospective and pseudorandomized study that included 196 patients (representing 104 and 92 livers preserved in UWS and CS, respectively) at La Fe University Hospital (Valencia, Spain) between March 2003 and May 2005. PNF and PDF rates, liver function laboratory parameters, postoperative bleeding, vascular and biliary complications, and patient and graft survival at 3 years were compared for the 2 groups. The 2 groups were similar in terms of donor variables, recipient variables, and surgical techniques. The PNF rates were 2.2% and 1.9% in the CS and UWS groups, respectively (P = not significant), and the PDF rates were 15.2% and 15.5% in the CS and UWS groups, respectively (P = not significant). There were no significant differences in the laboratory parameters for the 2 groups, except for alanine aminotransferase levels in month 3, which were lower in the CS group (P = 0.01). No significant differences were observed in terms of complications. Three-year patient and graft survival rates were as follows for years 1, 2, and 3: 83%, 80%, and 76% (patient) and 80%, 77%, and 73% (graft) for the UWS group and 83%, 77%, and 70% (patient) and 81%, 73%, and 67% (graft) for the CS group (P = not significant). In conclusion, this study shows that CS is as effective as UWS in liver preservation.
威斯康星大学溶液（UWS）是移植保存的金标准。塞尔西奥溶液（CS）是一种新的保存溶液，尚未广泛应用于肝移植。本研究旨在比较这两种保存液保存的移植供肝的肝功能。主要终点是原发性无功能（PNF）和原发性功能障碍（PDF）的发生率。我们进行了一项前瞻性、伪随机研究，该研究纳入了 2003 年 3 月至 2005 年 5 月期间在西班牙巴伦西亚 La Fe 大学医院的 196 例患者（分别代表 UWS 和 CS 保存的 104 例和 92 例肝脏）。比较两组患者的 PNF 和 PDF 发生率、肝功能实验室参数、术后出血、血管和胆道并发症以及 3 年时患者和移植物存活率。两组患者的供者变量、受者变量和手术技术相似。CS 组和 UWS 组的 PNF 发生率分别为 2.2%和 1.9%（P=无显著差异），PDF 发生率分别为 15.2%和 15.5%（P=无显著差异）。两组实验室参数无显著差异，除第 3 个月丙氨酸氨基转移酶水平较低外（P=0.01）。并发症方面无显著差异。3 年时患者和移植物存活率如下：第 1、2 和 3 年分别为 83%、80%和 76%（患者）和 80%、77%和 73%（移植物）（UWS 组）和 83%、77%和 70%（患者）和 81%、73%和 67%（移植物）（CS 组）（P=无显著差异）。总之，本研究表明 CS 在肝保存方面与 UWS 一样有效。
