Zhu Chenhui, Fan Daidi, Ma Xiaoxuan, Xue Wenjiao, Hui Junfeng, Chen Lan, Duan Zhiguang, Ma Pu
Shaanxi Key Laboratory of Degradable Biomedical Materials, Northwest University, Xi'an 710069, China.
Sheng Wu Gong Cheng Xue Bao. 2009 Aug;25(8):1225-33.
In order to improve tensile property of vascular scaffold, we blended silk fibroin with novel human-like collagen with the mass ratio of 9:1, 7:3 and 5:5 (W/W), and then fabricated blood vessel tubular graft by freeze-drying process. We studied microstructure, mechanical properties, elements composites, degradability and biocompatibility of vascular scaffolds. These results showed that tubular scaffold with mass ratio 7:3 exhibited interconnected porous structure with pore size at (60 +/- 5) microm and porosity of 85%; achieved the desirable mechanical property (strain of 50% +/- 5% and stress of 332 +/- 16 kPa); had relatively slow degradation rate; could enhance cell adhesion and proliferation and had superior biocompatibility.
为了提高血管支架的拉伸性能，我们将丝素蛋白与新型类人胶原蛋白按质量比9:1、7:3和5:5（W/W）进行混合，然后通过冷冻干燥工艺制备血管管状移植物。我们研究了血管支架的微观结构、力学性能、元素组成、降解性和生物相容性。这些结果表明，质量比为7:3的管状支架呈现出相互连通的多孔结构，孔径为（60±5）微米，孔隙率为85%；具有理想的力学性能（应变50%±5%，应力332±16千帕）；降解速率相对较慢；能够增强细胞黏附和增殖，具有优异的生物相容性。
