Gera Manoj, Saharan Vikas A, Kataria Mahesh, Kukkar Vipin
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Recent Pat Drug Deliv Formul. 2010 Jan;4(1):58-81. doi: 10.2174/187221110789957200.
Modification of the surface properties of particles, which is usually achieved by coating, is desirable to maintain and enhance the utility of these particles. Saving of time, energy, number of additives, process steps and consequently, the cost of the coating process leads to development of dry coating processes using mechanical methods which exclude any liquid solvent or binder solution and are environmentally safe, and cost-effective. Mechanofusion, hybridization, magnetic assisted impaction coating, theta-composer, rotating fluidized bed coating, pressure swing granulation and high shear mixing have been extensively patented and reported in the scientific literature. These mechanical methods have found multidisciplinary applications in drug development and drug delivery. Various devices available for the dry coating process, their principle, method of working, benefits and limitations along with various applications relevant to the pharmaceutical field are discussed in the current article.
颗粒表面性质的改变通常通过包衣来实现，这对于维持和提高这些颗粒的效用是很有必要的。节省时间、能源、添加剂数量、工艺步骤以及包衣过程的成本，促使了使用机械方法的干包衣工艺的发展，这些方法不使用任何液体溶剂或粘合剂溶液，对环境安全且具有成本效益。机械融合、杂交、磁辅助冲击包衣、θ混合器、旋转流化床包衣、变压造粒和高剪切混合已获得广泛专利，并在科学文献中有报道。这些机械方法在药物开发和药物递送中已得到多学科应用。本文讨论了可用于干包衣工艺的各种设备、其原理、工作方法、优点和局限性以及与制药领域相关的各种应用。
