Department of Immunochemistry, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R. Weigla, 53-114 Wrocław, Poland.
Curr Alzheimer Res. 2010 Jun;7(4):323-33. doi: 10.2174/156720510791162377.
A proline-rich polypeptide complex (PRP), subsequently called Colostrinin(CLN), was first isolated from ovine colostrum, was shown to possess immunoregulatory properties, including effects on the maturation and differentiation of murine thymocytes and humoral and cellular immune responses, both in vivo and in vitro. PRP seems to restore balance in cellular immune functions and is not species specific. PRP is a complex of peptides of molecular masses ranging from 500 to 3000 Da. The polypeptide contains 25% proline and 40% hydrophobic amino acids. PRP shows a regulatory activity in cytokine (IFN, TNF-alpha, IL-6, IL-10) induction and possesses the ability to inhibit the overproduction of oxygen reactive species and nitric oxide. Besides its immunoregulatory activity, PRP also showed psychotropic properties, improving cognitive activity and behavior of old rats, humans, and chickens. The properties of PRP prompted the authors to propose the complex for the treatment neurodegenerative disorders. Beneficial effects of PRP/Colostrinin were shown for the first time in double-blind placebo-controlled trials and long-term open-label studies. The results were confirmed in multicenter clinical trials. A very important property of PRP/Colostrinin is the prevention of Abeta aggregation and the disruption of already existing aggregates. The same properties were expressed by one of PRP's components, a nonapeptide (NP). Moreover, PRP modulates neurite outgrowth, suppresses uncontrolled activation of cells, reduces 4-HNE-mediated cellular damage, and modulates expression in cellular redox regulation, cell proliferation, and differentiation. Its biological response modifying activity can play an important role in its use in the treatment of Alzheimer's disease.
一种脯氨酸丰富的多肽复合物（PRP），随后被称为 Colostrinin（CLN），最初从绵羊初乳中分离出来，被证明具有免疫调节特性，包括对体内和体外的小鼠胸腺细胞的成熟和分化以及体液和细胞免疫反应的影响。PRP 似乎恢复了细胞免疫功能的平衡，并且没有种属特异性。PRP 是一种分子量在 500 至 3000 Da 之间的肽的复合物。该多肽含有 25%的脯氨酸和 40%的疏水性氨基酸。PRP 在细胞因子（IFN、TNF-α、IL-6、IL-10）诱导中表现出调节活性，并且具有抑制氧反应性物质和一氧化氮过度产生的能力。除了其免疫调节活性外，PRP 还表现出精神活性，改善老年大鼠、人类和鸡的认知活动和行为。PRP 的这些特性促使作者提出该复合物用于治疗神经退行性疾病。在双盲安慰剂对照试验和长期开放标签研究中首次显示出 PRP/Colostrinin 的有益作用。这些结果在多中心临床试验中得到了证实。PRP/Colostrinin 的一个非常重要的特性是预防 Abeta 聚集和破坏已经存在的聚集物。PRP 的一种成分，一种九肽（NP），也具有相同的特性。此外，PRP 调节神经突生长，抑制细胞失控激活，减少 4-HNE 介导的细胞损伤，并调节细胞氧化还原调节、细胞增殖和分化中的表达。其生物反应修饰活性在其用于治疗阿尔茨海默病方面可以发挥重要作用。
