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载脂蛋白在人体内从血浆脂蛋白进入外周淋巴脂蛋白的过程。

The passage of apoproteins from plasma lipoproteins into the lipoproteins of peripheral lymph in man.

作者信息

Reichl D, Myant N B, Pflug J J, Rudra D N

出版信息

Clin Sci Mol Med. 1977 Sep;53(3):221-6. doi: 10.1042/cs0530221.

DOI:10.1042/cs0530221
PMID:199396
Abstract
  1. The transport of apoprotein B from the lipoprotein of plasma into the lipoproteins of lymph draining the foot has been studied in four men with type III hyperlipoproteinaemia. 2. Three subjects were given autologous 125I-labelled very-low-density lipoprotein (VLDL) and 131I-labelled low-density lipoprotein (LDL) by intravenous injection; the fourth was given autologous 125I-labelled VLDL and 131I-labelled intermediate-density lipoprotein (IDL) plus LDL. 3. The 125I/131I ratios in serum and lymph apoprotein B, and the 125I and 131I specific radioactivities of apoprotein B in VLDL, IDL and LDL from serum and lymph, indicate that apoprotein B in the circulating VLDL can reach peripherallymph without the intermediacy of circulating LDL.
摘要
  1. 对4名Ⅲ型高脂蛋白血症男性患者,研究了载脂蛋白B从血浆脂蛋白转运至引流足部的淋巴液脂蛋白中的情况。2. 3名受试者通过静脉注射给予自体125I标记的极低密度脂蛋白(VLDL)和131I标记的低密度脂蛋白(LDL);第4名受试者给予自体125I标记的VLDL和131I标记的中间密度脂蛋白(IDL)加LDL。3. 血清和淋巴载脂蛋白B中的125I/131I比值,以及血清和淋巴中VLDL、IDL和LDL中载脂蛋白B的125I和131I比放射性,表明循环中的VLDL中的载脂蛋白B可在无循环LDL介导的情况下到达外周淋巴。

相似文献

1
The passage of apoproteins from plasma lipoproteins into the lipoproteins of peripheral lymph in man.载脂蛋白在人体内从血浆脂蛋白进入外周淋巴脂蛋白的过程。
Clin Sci Mol Med. 1977 Sep;53(3):221-6. doi: 10.1042/cs0530221.
2
Observations on the passage of apoproteins from plasma lipoproteins into peripheral lymph in two men.
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Quantitative studies of very low density lipoprotein: conversion to low density lipoprotein in normal controls and primary hyperlipidaemic states and the role of direct secretion of low density lipoprotein in heterozygous familial hypercholesterolaemia.极低密度脂蛋白的定量研究:正常对照和原发性高脂血症状态下极低密度脂蛋白向低密度脂蛋白的转化以及杂合子家族性高胆固醇血症中低密度脂蛋白直接分泌的作用。
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Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.在WHHL兔中,极低密度脂蛋白和中间密度脂蛋白清除延迟,向低密度脂蛋白的转化增强。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5693-7. doi: 10.1073/pnas.79.18.5693.
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Conversion of very low density lipoprotein to low density lipoprotein. A metabolic study of apolipoprotein B kinetics in human subjects.极低密度脂蛋白向低密度脂蛋白的转化。人体载脂蛋白B动力学的代谢研究。
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Catabolism of very low density lipoprotein B apoprotein in man.人体内极低密度脂蛋白B载脂蛋白的分解代谢
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Lipoprotein metabolism in the suckling rat: characterization of plasma and lymphatic lipoproteins.乳鼠的脂蛋白代谢:血浆和淋巴脂蛋白的特征
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Development of an integrated model for analysis of the kinetics of apolipoprotein B in plasma very low density lipoproteins, intermediate density lipoproteins, and low density lipoproteins.开发一种综合模型,用于分析血浆极低密度脂蛋白、中间密度脂蛋白和低密度脂蛋白中载脂蛋白B的动力学。
J Clin Invest. 1985 Aug;76(2):575-85. doi: 10.1172/JCI112009.

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