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血管内动脉瘤修复(EVAR)后的二级干预和移植物监测的持久价值。

Secondary interventions following endovascular aneurysm repair (EVAR) and the enduring value of graft surveillance.

机构信息

St George's Vascular Institute, St James' Wing, St George's Hospital, Blackshaw Road, London SW17 0QT, UK.

出版信息

Eur J Vasc Endovasc Surg. 2010 May;39(5):547-54. doi: 10.1016/j.ejvs.2009.11.002. Epub 2009 Nov 25.

Abstract

OBJECTIVE

Lifelong imaging surveillance is currently recommended for all patients following endovascular aortic aneurysm repair (EVR). The modality, timing and overall necessity of surveillance has recently been brought into question. This review reports contemporary secondary intervention rates and explores surveillance imaging pick-up rates and reports the evidence supporting modified EVR surveillance programs.

DESIGN

Systematic review of literature (2002-2009) and meta-analysis of Kaplan-Meier re-intervention-free survival estimates.

RESULTS

32 Papers were included in final analysis. 17,987 EVR cases were reported. Crude annual secondary intervention rates from the US population registries were 3.7%/year (range 1.7-4.3%). Combined re-intervention-free survival estimates, from 14 series (10,365 cases), demonstrated a linear progression with 89.9%, 86.9% and 81.5% of grafts without secondary procedures at 2, 3 and 5 years respectively. 3 Reports (1249 cases) differentiated between interventions directed by surveillance or outside surveillance protocols. Surveillance imaging alone initiated the secondary interventions in 1.4-9% of cases; >90% of EVR cases received no benefits from surveillance scans.

DISCUSSION

Some format of surveillance following EVR probably remains necessary despite a reduction in secondary interventions with modern stent-grafts. Surveillance should be targeted at those stent-grafts and patients at high risk of complications. Further work is justified to identify this group.

摘要

目的

目前建议所有接受血管内主动脉瘤修复(EVR)的患者进行终身影像学监测。最近,监测的方式、时间和整体必要性受到了质疑。本综述报告了当代二次干预率,并探讨了监测成像的检出率,并报告了支持改良 EVR 监测计划的证据。

设计

对文献(2002-2009 年)进行系统回顾和 Kaplan-Meier 再干预无事件生存率的荟萃分析。

结果

最终分析纳入 32 篇论文。报告了 17987 例 EVR 病例。来自美国人群登记处的原始年度二次干预率为 3.7%/年(范围 1.7-4.3%)。来自 14 项研究(10365 例)的综合再干预无事件生存率估计显示,随着时间的推移呈线性进展,分别有 89.9%、86.9%和 81.5%的移植物在 2、3 和 5 年内无需二次手术。有 3 篇报告(1249 例)区分了根据监测或监测协议以外的干预措施。单独的监测成像仅在 1.4%-9%的病例中引发了二次干预;超过 90%的 EVR 病例从监测扫描中没有获益。

讨论

尽管现代支架移植术后二次干预有所减少,但 EVR 后可能仍需要某种形式的监测。监测应针对那些支架移植物和并发症风险高的患者。进一步的工作是合理的,以确定这一群体。

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