VERIFIN, University of Helsinki, PO Box 55, FIN-00014 Helsinki, Finland.
J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 15;878(17-18):1365-81. doi: 10.1016/j.jchromb.2009.10.030. Epub 2009 Nov 5.
This review presents with selected examples the versatility of nuclear magnetic resonance (NMR) spectroscopy in the analysis of toxic organophosphorus (OP) compounds, i.e. OP pesticides and chemical warfare agents (CWAs). Several NMR applications of biological importance, like studies on inhibition mechanism, metabolism, and exposure determination, are presented. The review also concerns with the environmental analysis of OP compounds by NMR spectroscopy. Residue analysis of environment and food samples as well as characterization of degradation in environment is discussed. Some of the NMR studies that have been done to support the Chemical Weapons Convention, i.e. the development of suitable CWA detoxification means and the method development of verification analysis for CWAs and their degradation products, are outlined.
本文通过精选的实例，展示了核磁共振（NMR）光谱在分析有毒有机磷（OP）化合物（即 OP 农药和化学战剂（CWA））方面的多功能性。介绍了一些具有重要生物学意义的 NMR 应用，如抑制机制、代谢和暴露测定研究。本文还涉及通过 NMR 光谱法对 OP 化合物进行环境分析。讨论了环境和食品样品中 OP 化合物的残留分析以及环境中降解的特征。概述了一些支持《化学武器公约》的 NMR 研究，例如开发合适的 CWA 解毒方法以及开发用于 CWA 及其降解产物的验证分析方法。
