Clínica EUGIN, calle Entença 293-295, 08029 Barcelona, Spain.
Hum Reprod. 2010 Feb;25(2):436-42. doi: 10.1093/humrep/dep414. Epub 2009 Nov 24.
Race and ethnicity are one of the newly investigated patient-related prognostic factors that might affect the outcome of assisted reproduction techniques. To our knowledge no data currently are available on the effect of race on oocyte donation outcome.
A retrospective, matched cohort study was performed in a private infertility centre evaluating 1012 Black, South-East Asian and Caucasian recipients undergoing their first oocyte donation cycles.
A significantly lower ongoing pregnancy rate (24.6 versus 36.8%, OR: 0.56 95% CI: 0.40-0.77, P = 0.01) was observed among Black recipients compared with their matched Caucasian counterparts. The prevalence of uterine fibroids (49.6 versus 17.1%, P < 0.0001) and previous history of tubal infertility (53.2 versus 16.5%, P < 0.0001) was significantly higher among Black women. Multiple logistic regression analysis showed that, after adjusting for confounding variables, Black race was an independent risk factor for not achieving an ongoing pregnancy (for ongoing pregnancy, adjusted OR: 0.62 95% CI: 0.43-0.89, P = 0.009). Ongoing pregnancy rate (37.2 versus 37.2%, OR: 1.0 95% CI: 0.49-2.04, P = 1.0) was not significantly different between South-East Asian and matched Caucasian patients.
Black race was an independent risk factor for not achieving an ongoing pregnancy after oocyte donation. Although yellow race does not seem to adversely affect oocyte donation, larger studies are still warranted to draw more solid conclusions. Race should be considered as an independent prognostic factor in oocyte donation.
种族和民族是新研究的与患者相关的预后因素之一，可能影响辅助生殖技术的结局。据我们所知，目前尚无关于种族对卵母细胞捐赠结局影响的数据。
在一家私人不孕不育中心进行了一项回顾性、匹配队列研究，评估了 1012 名接受首次卵母细胞捐赠周期的黑人、东南亚裔和白种人患者。
与匹配的白种人患者相比，黑人患者的持续妊娠率明显较低（24.6%对 36.8%，OR：0.56，95%CI：0.40-0.77，P=0.01）。黑人患者中子宫肌瘤（49.6%对 17.1%，P<0.0001）和既往输卵管性不孕（53.2%对 16.5%，P<0.0001）的患病率明显较高。多因素逻辑回归分析显示，调整混杂变量后，黑人种族是未获得持续妊娠的独立危险因素（对于持续妊娠，调整后的 OR：0.62，95%CI：0.43-0.89，P=0.009）。东南亚裔和匹配的白种人患者的持续妊娠率（37.2%对 37.2%，OR：1.0，95%CI：0.49-2.04，P=1.0）无显著差异。
在卵母细胞捐赠后，黑人种族是未获得持续妊娠的独立危险因素。虽然黄种人似乎不会对卵母细胞捐赠产生不利影响，但仍需要更大的研究来得出更确凿的结论。种族应被视为卵母细胞捐赠的独立预后因素。
