T细胞对GAD65的反应在1型糖尿病中是否有影响？ - Suppr

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Are T-cell responses to GAD65 influential in type 1 diabetes?

作者信息

Quinn Anthony

机构信息

Department of Biological Sciences, University of Toledo, Toledo, Ohio, USA.

出版信息

Diabetes. 2009 Dec;58(12):2729-30. doi: 10.2337/db09-1445.

DOI:10.2337/db09-1445

PMID:19940237

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2780881/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f3/2780881/2e8472cb2cd4/zdb0120959730001.jpg

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Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease.自身抗原谷氨酸脱羧酶65（GAD65）转基因的广泛表达不能使非肥胖型糖尿病小鼠产生免疫耐受，反而会加剧疾病。

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Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology.用GAD65对糖尿病易感性或非糖尿病易感性小鼠进行免疫接种，不会诱发糖尿病或胰岛细胞病变。

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Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice.诱导GAD65特异性调节性T细胞可抑制非肥胖糖尿病小鼠中持续的自身免疫性糖尿病。

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本文引用的文献

Diabetes. 2009 Dec;58(12):2843-50. doi: 10.2337/db08-0851. Epub 2009 Sep 9.

Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes.

J Autoimmun. 2009 Mar;32(2):104-9. doi: 10.1016/j.jaut.2009.01.001. Epub 2009 Feb 1.

Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.人类自身反应性谷氨酸脱羧酶特异性T细胞中的差异识别和激活阈值

Diabetes. 2004 Apr;53(4):971-7. doi: 10.2337/diabetes.53.4.971.

Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model.在1型糖尿病模型中，生理性β细胞死亡会触发树突状细胞对自身反应性T细胞的致敏。

J Exp Med. 2003 Nov 17;198(10):1527-37. doi: 10.1084/jem.20030966.

Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase.对谷氨酸脱羧酶耐受的非肥胖糖尿病（NOD）小鼠中糖尿病的正常发病率。

J Exp Med. 2003 Jun 16;197(12):1635-44. doi: 10.1084/jem.20030215. Epub 2003 Jun 9.

Conversations with GAD.与广泛性焦虑障碍的对话。

J Autoimmun. 2003 May;20(3):195-8. doi: 10.1016/s0896-8411(03)00031-3.

Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes.1型糖尿病高危儿童中轮状病毒感染与胰岛自身免疫的关联。

Diabetes. 2000 Aug;49(8):1319-24. doi: 10.2337/diabetes.49.8.1319.

Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells.通过在β细胞中表达或抑制谷氨酸脱羧酶（GAD）来控制非肥胖糖尿病（NOD）小鼠的自身免疫性糖尿病。

Science. 1999 May 14;284(5417):1183-7. doi: 10.1126/science.284.5417.1183.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10055-60. doi: 10.1073/pnas.95.17.10055.

Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry.柯萨奇病毒诱导的糖尿病：由旁观者损伤引发而非分子模拟。

Nat Med. 1998 Jul;4(7):781-5. doi: 10.1038/nm0798-781.

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