唐氏综合征患者孕中期羊水中瘦素水平降低。
Decreased amniotic fluid leptin levels in the second trimester in Down's syndrome.
机构信息
Pediatric Cardiac Center, Pusan National University Children's Hospital, Busan, Korea.
出版信息
Fetal Diagn Ther. 2009;26(4):195-9. doi: 10.1159/000262280. Epub 2009 Nov 25.
OBJECTIVE
To investigate a possible role of leptin contributing to the pathophysiology of Down's syndrome by assessing amniotic fluid leptin levels in the 2nd trimester of normal pregnancy and pregnancy complicated by Down's syndrome.
METHODS
We retrospectively assessed leptin levels of 2nd trimester amniotic fluid from 15 pregnancies diagnosed with Down's syndrome and 15 matched unaffected singleton pregnancies (controls). All amniotic fluid samples were obtained from women undergoing genetic amniocentesis at 16-20 weeks of gestation. Leptin levels were measured by enzyme-linked immunosorbent assay.
RESULTS
Amniotic fluid leptin levels were significantly decreased in the Down's syndrome group (3.26 +/- 2.36 ng/ml) compared to the controls (8.26 +/- 9.11 ng/ml, p < 0.05).
CONCLUSION
This study showed significantly decreased leptin levels in the 2nd trimester amniotic fluid of fetuses with Down's syndrome. This result suggests a possible role of leptin in the pathophysiology of Down's syndrome during the fetal period.
目的
通过评估正常妊娠和唐氏综合征妊娠中孕期羊水中瘦素水平，研究瘦素在唐氏综合征病理生理学中的可能作用。
方法
我们回顾性评估了 15 例唐氏综合征和 15 例匹配的正常单胎妊娠（对照组）孕妇中孕期羊水中瘦素水平。所有羊水样本均取自 16-20 周行遗传羊膜穿刺术的孕妇。通过酶联免疫吸附试验测量瘦素水平。
结果
唐氏综合征组羊水瘦素水平明显低于对照组（3.26 +/- 2.36 ng/ml 比 8.26 +/- 9.11 ng/ml，p < 0.05）。
结论
本研究显示唐氏综合征胎儿中孕期羊水中瘦素水平明显降低。这一结果提示瘦素可能在胎儿期唐氏综合征的病理生理学中发挥作用。
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