Department of Neurology, University Hospital, Cracow, Poland.
Dement Geriatr Cogn Disord. 2009;28(5):461-4. doi: 10.1159/000259460. Epub 2009 Nov 20.
Interleukin-1 is a potent proinflammatory cytokine involved in the pathophysiology of Alzheimer's disease (AD). We genotyped IL-1beta (-511 C/T) and the apolipoprotein E (APOE) common polymorphisms in a large case-controlled study in a Polish population. We included 332 patients with late-onset AD and 220 controls without any neurological deficit, cognitive complaints and history of neurological diseases, aged > or = 65 years. The distribution of the IL-1beta (-511 C/T) genotypes was similar to that in the controls (AD: C/C = 45.8%, C/T = 44.6%, T/T = 9.6% vs. controls: C/C = 53.9%, C/T = 38.3%, T/T = 7.3%, p > 0.05). Our study confirms previous reports that APOE epsilon4 is strongly related to the risk of AD (odds ratio = 6.60, 95% confidence interval 4.19-10.41). APOE status did not affect the distribution of the studied IL-1beta polymorphism. The IL-1beta (-511 C/T) polymorphism is not a risk factor for late-onset AD in a Polish population.
白细胞介素-1 是一种有效的促炎细胞因子，参与阿尔茨海默病 (AD) 的病理生理学。我们在波兰的一项大型病例对照研究中对白细胞介素-1β (-511 C/T) 和载脂蛋白 E (APOE) 常见多态性进行了基因分型。我们纳入了 332 名晚发性 AD 患者和 220 名无任何神经功能缺损、认知障碍和神经病史、年龄≥65 岁的对照组。白细胞介素-1β (-511 C/T) 基因型的分布与对照组相似（AD：C/C=45.8%，C/T=44.6%，T/T=9.6% vs. 对照组：C/C=53.9%，C/T=38.3%，T/T=7.3%，p＞0.05）。我们的研究证实了先前的报告，即 APOE ε4 与 AD 的风险密切相关（比值比=6.60，95%置信区间 4.19-10.41）。APOE 状态并不影响所研究的白细胞介素-1β多态性的分布。白细胞介素-1β (-511 C/T) 多态性不是波兰人群晚发性 AD 的危险因素。
