慢性应激与遗忘型轻度认知障碍患者的皮质醇水平升高和情绪应对机制有关。
Chronic stress is associated with high cortisol levels and emotional coping mechanisms in amnestic mild cognitive impairment.
机构信息
Department of Medical-Surgical Nursing, School of Nursing, University of São Paulo, São Paulo, Brazil.
出版信息
Dement Geriatr Cogn Disord. 2009;28(5):465-70. doi: 10.1159/000259696. Epub 2009 Nov 23.
BACKGROUND/AIMS: To investigate the association between cortisol levels, chronic stress and coping in subjects with amnestic-type mild cognitive impairment (aMCI).
METHODS
Cortisol levels were measured using morning saliva samples from 33 individuals with aMCI and from 41 healthy elderly. Chronic stress was evaluated with the Stress Symptoms List (SSL), whereas coping strategies were assessed using the Jalowiec Coping Scale.
RESULTS
aMCI subjects with high SSL scores presented higher cortisol levels (p = 0.045). Furthermore, aMCI subjects who employed emotion-focused coping had higher SSL scores (p = 0.023).
CONCLUSION
The association between increased cortisol secretion, chronic stress and coping strategies may be modulated by the presence or absence of cognitive impairment, where memory defi- cit awareness constitutes an additional potential factor involved in high stress severity.
背景/目的：探讨遗忘型轻度认知障碍（aMCI）患者皮质醇水平、慢性应激与应对方式之间的关系。
方法
采用清晨唾液样本测量 33 例 aMCI 患者和 41 例健康老年人的皮质醇水平。采用应激症状清单（SSL）评估慢性应激，采用 Jalowiec 应对量表评估应对策略。
结果
SSL 评分高的 aMCI 患者皮质醇水平较高（p = 0.045）。此外，采用情绪聚焦应对方式的 aMCI 患者 SSL 评分较高（p = 0.023）。
结论
皮质醇分泌增加、慢性应激与应对策略之间的关联可能受到认知障碍的存在与否的调节，其中记忆缺陷的认识构成了高应激严重程度的另一个潜在因素。
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