类胰蛋白酶不能经肾脏清除到尿液中。
Tryptase is not cleared by the kidneys into the urine.
机构信息
Allergy and Immunology Section, William Beaumont Hospital, Royal Oak, MI 48073, USA.
出版信息
Int Arch Allergy Immunol. 2010;152(1):28-31. doi: 10.1159/000260080. Epub 2009 Nov 24.
Abstract
BACKGROUND
Patients with chronic kidney disease have been reported to have increased concentrations of blood tryptase. Detection of tryptase in the urine of healthy subjects has been reported.
OBJECTIVE
The objective is to determine whether tryptase is indeed cleared by the kidneys.
METHODS
Blood and urine collections were performed in healthy and systemic mastocytosis subjects. Total and mature tryptase concentrations in blood and total tryptase concentrations in urine were determined.
RESULTS
Total tryptase levels in urine were below the limit of detection in both healthy subjects and those with systemic mastocytosis, even after concentrating the urine 10-fold. Thus, both mature and protryptase levels in urine are <0.2 ng/ml.
CONCLUSION
Tryptase is not cleared by the kidneys into the urine.
摘要
背景
据报道，慢性肾脏病患者血液中的胰蛋白酶浓度升高。已有报道称在健康受试者的尿液中检测到胰蛋白酶。
目的
本研究旨在确定胰蛋白酶是否确实通过肾脏清除。
方法
在健康受试者和系统性肥大细胞增多症患者中进行血液和尿液采集。测定血液中的总胰蛋白酶和成熟胰蛋白酶浓度以及尿液中的总胰蛋白酶浓度。
结果
即使将尿液浓缩 10 倍，健康受试者和系统性肥大细胞增多症患者的尿液中总胰蛋白酶水平仍低于检测限。因此，尿液中的成熟胰蛋白酶和前胰蛋白酶水平均<0.2ng/ml。
结论
胰蛋白酶不能通过肾脏排入尿液。
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